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31362-50-2

31362-50-2 structure

31362-50-2 structure

Name: Bombesin
Chemical Name: Bombesin
CAS Number: 31362-50-2
Molecular Formula: C₇₁H₁₁₀N₂₄O₁₈S
Molecular Weight: 1619.85000
Catalog: Biochemical Peptide
Create Date: 2018-06-12 13:10:14
Modify Date: 2026-06-30 17:06:35
Bombesin is a tetradecapeptide originally isolated from frog skin; plays an important role in the release of gastrin and the activation of G-protein receptors.

Name	Bombesin
Synonyms	PYROGLU-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET NH2 Bombesin hydrate acetate salt (S)-N1-((5S,8S,11S,17S,20S,23S,26S,29S,35S,38S)-11-((1H-Imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-43-amino-29-(2-amino-2-oxoethyl)-26-(3-amino-3-oxopropyl)-5-cbamoyl-43-imino-8,35-diisobutyl-17-isopropyl-20-methyl-7,10,13,16,19,22,25,28,31,34,37 M.W. 1619.85 C71H110N24O18S BOMBESIN ACETATE SALT 2-l-glutamine-6-l-aspagine-alytesin MFCD00167514 Bombesin acetate salt hydrate BOMBESIN SYNTHETIC STIMULATES GASTR IN RE Bombesin acetate salt hydrate, (HPLC) bombesin acetate hydrate PYR-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 ACOH 7H2O Bombesin trifluoroacetate salt Pyr-Gln-g-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 trifluoroacetate salt Alphaxalone 5-Oxo-L-Pro-L-Gln-L-g-L-Leu-Gly-L-Asn-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Leu-L-Met-NH2 PGLU-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 H-PYR-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 PYR-QRLGNQWAVGHLM-NH2 GLP-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 (S)-N1-((5S,8S,11S,17S,20S,23S,26S,29S,35S,38S)-11-((1H-Imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-43-amino-29-(2-amino-2-oxoethyl)-26-(3-amino-3-oxopropyl)-5-cbamoyl-43-imino-8,35-diisobutyl-17-isopropyl-20-methyl-7,10,13,16,19,22,25,28,31,34,37-undecaoxo-2-thia-6,9,12,15,18,21,24,27,30,33,36,42-dodecaazatritetracontan-38-yl)-2-((S)-5-oxopyrrolidine-2-cboxamido)pentanediamide Bombesin, Free Base bombesin acetate Bombesin //BP C71H110N24O18S 2-l-glutamine-6-l-aspagine-alytesi pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Bastrin PYR-GLN-G-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 BOMBESIN ACOH 7H2O

Description	Bombesin is a tetradecapeptide originally isolated from frog skin; plays an important role in the release of gastrin and the activation of G-protein receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others Peptides
In Vitro	Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB)[1]. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus[2]. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC50=1 nM)[3].
References	[1]. Gonzalez N, et al. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):58-64. [2]. Chejfec G, et al. Bombesin in human neuroendocrine (NE) neoplasms. Peptides. 1985;6 Suppl 3:107-12.

Density	1.5g/cm3
Molecular Formula	C₇₁H₁₁₀N₂₄O₁₈S
Molecular Weight	1619.85000
Exact Mass	1618.82000
PSA	711.43000
LogP	2.59880
Index of Refraction	1.681
Storage condition	−20°C
Water Solubility	0.05 M acetic acid: 20 mg/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD3480000

CHEMICAL NAME :: Alytesin, 2-L-glutamine-6-L-asparagine-

CAS REGISTRY NUMBER :: 31362-50-2

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C71-H110-N24-O18-S

MOLECULAR WEIGHT :: 1620.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 270,97,1992

Hazard Codes	F+
Safety Phrases	22-24/25
WGK Germany	3
RTECS	BD3480000

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