Name | (2R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid |
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Synonyms |
D-Cpp-ene
SDZ-EAA 494 Midafotel UNII-7LYU6ZF84G |
Description | Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects[1][2][3]. |
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Related Catalog | |
Target |
NMDA Receptor:39 nM () |
In Vivo | Midafotel (15 mg/kg;腹腔注射) 在大鼠中引起强烈的刻板行为[2]。 Midafotel (1.5、4.5、15 mg/kg;静脉注射;在 MCA 阻塞前 15 分钟开始 (随后以 1、3 或 10 mg/kg/h 持续输注)) 产生剂量依赖性体积减少梗死; 4.5 mg/kg剂量对大鼠局灶性脑缺血最有效[3]。 Animal Model: Adult female Wistar rats[2] Dosage: 15 mg/kg Administration: I.p. Result: Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum. |
References |
Molecular Formula | C8H15N2O5P |
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Molecular Weight | 250.19 |
Exact Mass | 250.07200 |
PSA | 119.91000 |
~59% 117414-74-1 |
Literature: Aebischer; Frey; Haerter; Herrling; Mueller; Olverman; Watkins Helvetica Chimica Acta, 1989 , vol. 72, # 5 p. 1043 - 1051 |
Precursor 0 | |
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DownStream 1 | |