(R)-CPPene(SDZ EAA 494)

Modify Date: 2025-08-25 06:31:56

(R)-CPPene(SDZ EAA 494) structure	Common Name	(R)-CPPene(SDZ EAA 494)
	CAS Number	117414-74-1	Molecular Weight	250.19
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₁₅N₂O₅P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (R)-CPPene(SDZ EAA 494)

Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects[1][2][3].

Name	(2R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid
Synonym	More Synonyms

Description	Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA Receptor:39 nM ()
In Vivo	Midafotel (15 mg/kg；腹腔注射) 在大鼠中引起强烈的刻板行为[2]。 Midafotel (1.5、4.5、15 mg/kg；静脉注射；在 MCA 阻塞前 15 分钟开始 (随后以 1、3 或 10 mg/kg/h 持续输注)) 产生剂量依赖性体积减少梗死; 4.5 mg/kg剂量对大鼠局灶性脑缺血最有效[3]。 Animal Model: Adult female Wistar rats[2] Dosage: 15 mg/kg Administration: I.p. Result: Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum.
References	[1]. Lowe DA, et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. [2]. Potschka H, et al. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur J Pharmacol. 1999 Jun 18;374(2):175-87. [3]. Park CK, McCulloch J, Kang JK, Choi CR. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Lett. 1992 Nov 23;147(1):41-4.

Molecular Formula	C₈H₁₅N₂O₅P
Molecular Weight	250.19
Exact Mass	250.07200
PSA	119.91000
InChIKey	VZXMZMJSGLFKQI-ABVWVHJUSA-N
SMILES	O=C(O)C1CN(CC=CP(=O)(O)O)CCN1

(R,E)-4-(3-(die...

CAS#:117414-78-5

~59%

(R)-CPPene(SDZ ...

CAS#:117414-74-1

Literature: Aebischer; Frey; Haerter; Herrling; Mueller; Olverman; Watkins Helvetica Chimica Acta, 1989 , vol. 72, # 5 p. 1043 - 1051

Precursor 0
DownStream 1
CAS#:126453-07-4 (R)-CPP(mM/ml)

D-Cpp-ene

SDZ-EAA 494

Midafotel

UNII-7LYU6ZF84G

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(R)-CPPene(SDZ EAA 494)

Use of (R)-CPPene(SDZ EAA 494)

Names

(R)-CPPene(SDZ EAA 494) Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.