147695-92-9

147695-92-9 structure

Name: ZM 226600
Chemical Name: N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
CAS Number: 147695-92-9
Molecular Formula: C₁₆H₁₄F₃NO₄S
Molecular Weight: 373.35
Create Date: 2016-10-22 16:26:05
Modify Date: 2024-03-01 17:02:44
ZM226600 is an ATP-sensitive potassium channel opener (EC50: 500 nM). ZM226600 inhibits bladder spontaneous activity[1][2].

Name	N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide

Description	ZM226600 is an ATP-sensitive potassium channel opener (EC50: 500 nM). ZM226600 inhibits bladder spontaneous activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	ZM226600 (1 μM, 30 min) 抑制膀胱自发活动[1].
In Vivo	ZM226600 (10-1000 nmol/kg，静脉注射) 不会显着改变麻醉大鼠的心跳率[1]。
References	[1]. Pinna C,et al. Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur J Pharmacol. 2005 May 23;516(1):71-7. [2]. Grant TL, et al. Anilide tertiary carbinols: a novel series of K+ channel openers. Trends Pharmacol Sci. 1994 Nov;15(11):402-4.