135661-44-8

135661-44-8 structure

Name: Sulfosuccinimidyl oleate
Chemical Name: 1-octadec-9-enoyloxy-2,5-dioxopyrrolidine-3-sulfonic acid,sodium
CAS Number: 135661-44-8
Molecular Formula: C₂₂H₃₆NNaO₇S
Molecular Weight: 481.57900
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-10-29 10:09:42
Modify Date: 2025-08-26 08:23:21
Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].

Name	1-octadec-9-enoyloxy-2,5-dioxopyrrolidine-3-sulfonic acid,sodium
Synonyms	sulfosuccinimidyl oleate 2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic Acid Sodium Sulfosuccinimidyl Oleate Sodium sulfo-N-succinimidyl oleate (Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium

Description	Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1]. Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1]. Cell Viability Assay[1] Cell Line: BV2 cells Concentration: 20 μM and 50 μM Incubation Time: 24 hours Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Western Blot Analysis[1] Cell Line: BV2 cells Concentration: 50 μM Incubation Time: 24 hours Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
In Vivo	Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1]. Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1] Dosage: 50 mg/kg Administration: Administered once by single oral gavage Result: Reduced brain damage following ischemia. Attenuated infarct size.
References	[1]. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.

Density	1.19g/cm3
Melting Point	220-222ºC
Molecular Formula	C₂₂H₃₆NNaO₇S
Molecular Weight	481.57900
Exact Mass	481.21100
PSA	129.26000
LogP	5.17350
Index of Refraction	1.526
Storage condition	-20°C

Hazard Codes	Xi

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

135661-44-8	162823-01-0
131068-49-0	106327-86-0
180028-78-8	102568-45-6
202057-28-1	112820-42-5
103963-69-5	102568-43-4
2741926-58-7	2742029-72-5
2742029-76-9	2745204-83-3
2742023-81-8	2741939-97-7
2138070-89-8	1856649-54-1
2742024-67-3	2892064-88-7