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Product Name: Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5a)-
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16590-41-3

16590-41-3 structure

16590-41-3 structure

Name: naltrexone
Chemical Name: naltrexone
CAS Number: 16590-41-3
Molecular Formula: C₂₀H₂₃NO₄
Molecular Weight: 341.40
Catalog: API Special medicine Antidote
Create Date: 2018-03-24 08:00:00
Modify Date: 2026-07-04 16:31:58
Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system[1].

Name	naltrexone
Synonyms	Dotrex NeMexin Trexonil Naltrexone //BP 17-(cyclopropylmethyl)-4,5-oxy-3,14-dihydroxymorphinan-6-one (1S,5R,13R,17S)-4-(Cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadeca-7(18),8,10-trien-14-on Depotrex ReVia Naltrexone (base, anhydrous) en1639 Naltrexone Naltrexone (1.0 mg/mL in Methanol) (5α)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one C07253 Vivitrex 3,14-Dihydroxy-17-(cyclopropylmethyl)-4,5α-oxymorphinan-6-one Nalorex Depade (5α)-17-(Cyclopropylmethyl)-4,5-oxy-3,14-dihydroxymorphinan-6-one (4R,4aS,7,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one Morphinan-6-one,17-(cyclopropylMethyl)-4,5-oxy-3,14-dihydroxy-, (5a) Naltrexone impurty NaltrexoneBase 4,5α-oxy-3,14β-dihydroxy-17-(cyclopropylmethyl)morphinan-6-one Naltrexone Hydrochloride Impurity 1 Naltrexone trifluoroacetate salt (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadeca-7(18),8,10-trien-14-one En 1639A Naltrexone (controlled) HCl en1939 Naltrel Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-oxy-3,14-dihydroxy-, (5α) Vivitrol Naltrexone solution Naltrexone (base and/or unspecified salts) Naltrexone Standd celupan Um-792 (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Adamantane Impurity 50 Naltrexone Base & HCL Naltrexone Base Monohydrate 17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydroxy-morphinan-6-on n-cyclopropylmethyl-14-hydroxydihydromorphinone Antaxone Naltrexone, 1.0 mg/mL trexan 5-oxy-3,14-dihydroxy-17-(cyclopropylmethyl)-(5-alpha)-morphinan-6-on (1S,5R,13R,17S)-4-(cyclopropylméthyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadéca-7(18),8,10-trién-14-one n-cyclopropylmethylnoroxymorphone

Description	Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
References	[1]. Couto RD, et al. Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer. Curr Drug Res Rev. 2021;13(2):86-89. [2]. Lobmaier PP, et al. Naltrexone depot formulations for opioid and alcohol dependence: a systematic review. CNS Neurosci Ther. 2011 Dec;17(6):629-36. [3]. Mannelli P, Peindl KS, Wu LT. Pharmacological enhancement of naltrexone treatment for opioid dependence: a review. Subst Abuse Rehabil. 2011 Jun;2011(2):113-123. [4]. Swift R, Oslin DW, Alexander M, Forman R. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. J Stud Alcohol Drugs. 2011 Nov;72(6):1012-8. [5]. Makowski CT, Gwinn KM, Hurren KM. Naltrexone/bupropion: an investigational combination for weight loss and maintenance. Obes Facts. 2011;4(6):489-94. [6]. Hulse GK. Improving Clinical Outcomes for Naltrexone as a Management of Problem Alcohol Use. Br J Clin Pharmacol. 2012 Sep 5. doi: 10.1111/j.1365-2125.2012.04452.x. [7]. Naltrexone

Density	1.5±0.1 g/cm3
Boiling Point	558.1±50.0 °C at 760 mmHg
Melting Point	168-170ºC
Molecular Formula	C₂₀H₂₃NO₄
Molecular Weight	341.40
Flash Point	291.4±30.1 °C
Exact Mass	341.162720
PSA	70.00000
LogP	1.80
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.709

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD2155000

CHEMICAL NAME :: Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy -

CAS REGISTRY NUMBER :: 16590-41-3

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C20-H23-N-O4

MOLECULAR WEIGHT :: 341.44

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P1- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 551 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1100 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 21 mg/kg

SEX/DURATION :: female 10-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 gm/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,180,1979

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

Precursor 9
1407490-23-6 52446-24-9 7051-34-5 16676-29-2
33522-95-1 1489-69-6 2516-33-8 16617-07-5
5911-08-0
DownStream 6
111555-53-4 55096-26-9 73232-52-7 105618-26-6
161532-22-5 16676-29-2

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