55096-26-9

55096-26-9 structure

Name: Nalmefene
Chemical Name: (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
CAS Number: 55096-26-9
Molecular Formula: C₂₁H₂₅NO₃
Molecular Weight: 339.43
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-09-18 16:22:43
Modify Date: 2026-07-12 20:57:46
Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence[1].

Name	(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
Synonyms	Revex Nalmefene d3 Nalmefenum Cervene 17-(Cyclopropylmethyl)-4,5α-oxy-6-methylenemorphinan-3,14-diol C08027 (5α)-17-4,5-oxy-6-methylenemorphinan-3,14-diol 6-Deoxo-6-methylenenaltrexone 6-desoxy-6-methylenenaltrexone (5alpha)-17-(cyclopropylmethyl)-4,5-oxy-6-methylenemorphinon-3,14-diol 4,5α-oxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol Alcofene 17-(cyclopropylmethyl)-4,5alpha-oxy-6-methylenemorphinan-3,14-diol (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol （Nalmefene hydrochloride） Arthene Morphinan-3,14-diol,17-(cyclopropylmethyl)-4,5-oxy-6-methylene-, (5a) Nalmetrene ORF-11676 Nalmetrenum [5ALPHA]-17-[CYCLOPROPYLMETHYL]-4,5-OXY-6-METHYLENEMORPHINAN-3,14-DIOL Nalmetreno (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol NALMEFENE Nalmefene-D7 (5α)-17-(cyclopropylmethyl)-4,5-oxy-6-methylenemorphinan-3,14-diol nalmetrene Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-oxy-6-methylene-, (5α) nalmefene 9a-(Cyclopropylmethyl)-4,5alpha-oxy-6-methylen-3,14-morphinandiol Nalmefene-d3Q: What is Nalmefene-d3 Q: What is the CAS Number of Nalmefene-d3

Description	Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	MOR, DOR, KOR[1]
References	[1]. Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16(3):471-5. [2]. Mann K, et al. Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. Eur Neuropsychopharmacol. 2016 Dec;26(12):1941-1949.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3

144265-45-2

55096-26-9

Literature: Synthetic Communications, , vol. 22, # 16 p. 2313 - 2327

16590-41-3

1779-49-3

55096-26-9

Literature: Journal of Medicinal Chemistry, , vol. 18, p. 259 - 262

Precursor 3
144265-45-2 16590-41-3 1779-49-3
DownStream 0