16326-32-2

16326-32-2 structure

Name: Methyl γ-linolenate
Chemical Name: Methyl γ-linolenate
CAS Number: 16326-32-2
Molecular Formula: C₁₉H₃₂O₂
Molecular Weight: 292.456
Catalog: analytical chemistry Standard Food and beverage standards
Create Date: 2018-09-03 12:01:33
Modify Date: 2026-07-01 10:15:11
γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of γ-Linolenic Acid (GLA), which is an ω-6 fatty acid, serves as melanoma cell proliferation inhibitors. γ-Linolenic Acid methyl ester inhibits ADP-induced blood platelet aggregation and induces apoptosis[1][2][3][4][5].

Name	Methyl γ-linolenate
Synonyms	6Z,9Z,12Z-OCTADECATRIENOIC ACID, METHYL ESTER Methyl g-linolenate @10.0 mg/mL in Htane Methyl 6-cis,9-cis,12-cis-octadecatrienoate γ-LINOLENIC ACID METHYL ESTER (6Z,9Z,12Z)-6,9,12-Octadecatrienoic acid methyl ester (6Z,9Z,12Z) Methyl (6Z,9Z,12Z)-octadeca-6,9,12-trienoate Methyl g-linolenate METHYLG-LINOLENATE ω-6 Linolenic acid methyl ester METHYL-GAMA-LINOLENATE 6,9,12-OCTADECATRIENOIC ACID METHYL ESTER Methyl (6Z,9Z,12Z)-Octadeca-6,9,12-trienoate C18:3 -12 Octadecatrienoic Acid Methyl Ester GAMMA-LINOLENIC ACID METHYL ESTE Methyl γ-linolenate(C18:3) Methyl (6Z,9Z,12Z)-6,9,12-octadecatrienoate (6Z,9Z,12Z)-Methyl octadeca-6,9,12-trienoate Caprylic Acid Impurity 72 METHYL (Z,Z,Z)-6,9,12-OCTADECATRIENOATE Methyl Gamma-Linolenate(C18:3) Gamma Linolenic Methyl Ester METHYL GAMMA-LINOLENATE C18:3n6 γ-Linolenic acid methyl ester in Htane DELTA 6 CIS 9 CIS 12 CIS OCTADECATRIENOIC ACID METHYL ESTER C18:3 (ALL CIS-6,9,12) METHYL ESTER γ-Linolenic acid methyl ester, ω-6 Linolenic acid methyl ester, 6,9,12-Octadecatrienoic acid methyl ester, Fame 18:3n-6, Methyl (Z,Z,Z)-6,9,12-octadecatrienoate All Cis -12 Octadecatrienoic Methyl Ester ALL CIS-6,9,12-OCTADECATRIENOIC ACID METHYL ESTER GAMMA-LINOLENIC ACID METHYL ESTER MFCD00010455 LIGAMO-007 γ-Linolenic Acid methyl ester γ-Linolenic Acid methyl ester (solution in ethanol) Methyl octadeca-6,9,12-trienoate METHYL GLA Methyl γ-linolenate solution 6,9,12-Octadecatrienoic acid, methyl ester, (6Z,9Z,12Z) Methyl-γ-linolenateQ: What is Methyl-γ-linolenate Q: What is the CAS Number of Methyl-γ-linolenate Q: What is the storage condition of Methyl-γ-linolenate Q: What e the applications of Methyl-γ-linolenate FAME 18:3N-6 Methyl γ-linolenate,γ-Linolenic acid methyl ester, ω-6 Linolenic acid methyl ester, 6,9,12-Octadecatrienoic acid methyl ester, Fame 18:3n-6, Methyl (Z,Z,Z)-6,9,12-octadecatrienoate Methyl y-linolenate Methyl gamma-linolenate solution

Description	γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of γ-Linolenic Acid (GLA), which is an ω-6 fatty acid, serves as melanoma cell proliferation inhibitors. γ-Linolenic Acid methyl ester inhibits ADP-induced blood platelet aggregation and induces apoptosis[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	γ-Linolenic Acid methyl ester (1-4 μg/mL; 72 h) induces apoptosis in vitro A-549 lung cancer cell lines using SRB assay. However GLA is due to its action at the gene/oncogene level and by altering BCl-2 expression[1]. Apoptosis Analysis[1] Cell Line: A-549 lung cancer cell line Concentration: 1, 2, 3, and 4 μg/mL Incubation Time: 72 hours; observed at 24 h, 48 h, and 72 h Result: Showed cytotoxicity potentially due to the induction of apoptosis of tumor cells by augmenting free radical generation only in the tumor cells but not normal cells.
In Vivo	γ-Linolenic Acid methyl ester decreases the hepatic triglycerides and histological evidence of fatty liver induced by EtOH[2]. γ-Linolenic Acid methyl ester could significantly decrease levels of plasma total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), MDA, atherosclerosis index (AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol (HDL-C) in both normal and hyperlipidemic rats[3]. Animal Model: Hepatic pathol rats model induced by EtOH (male Sprague-Dawley rats, 250-300 g)[2] Dosage: 90 mL, 50-60 mL Administration: Intraperitoneal injection; once daily; administrated 90 mL during day 1-5 and day 9, 50-60 mL during day 6-8 Result: Decreased the hepatic triglycerides of 25.6 mg/g compared with saline (40.2 mg/g) or olive oil (42.8 mg/g) treatment. Decreased liver index (the ratio of liver weight and body wight) in hyperlipidemic rats, but had no significant effect in normal rats.
References	[1]. Jubie S, et al. Isolation of methyl gamma linolenate from Spirulina platensis using flash chromatography and its apoptosis inducing effect. BMC Complement Altern Med. 2015 Aug 4;15:263. [2]. Segarnick DJ, et al. Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. Prostaglandins Leukot Med. 1985 Mar;17(3):277-82. [3]. Xiuqin K, et al. Studies on the hypolipidemic effects of gamma-linolenic acid methyl ester derived from Spirulina maxima[J]. Zhongguo hai Yang yao wu= Chinese Journal of Marine Drugs, 2003, 22(6): 30-34. [4]. Williams, et al. Antithrombosis agent containing γ-linolenic acid or a functional derivative of it: Federal Republic of Germany, DE2749492[P]. 1978-05-11. [5]. Hiyamuta, et al. Melanoma cell proliferation inhibitors containing γ-linolenic acid or its derivatives: Japan, JP2014141427[P]. 2014-08-07.

Density	0.9±0.1 g/cm3
Boiling Point	385.4±0.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₂O₂
Molecular Weight	292.456
Flash Point	101.5±23.2 °C
Exact Mass	292.240234
PSA	26.30000
LogP	7.03
Appearance	Liquid
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.476
Storage condition	−20°C

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F
Risk Phrases	11
Safety Phrases	16
RIDADR	UN 1993 / PGIII
WGK Germany	3
HS Code	2916190090

Precursor 8
30964-00-2 2067-33-6 56909-02-5 209860-40-2
67-56-1 186581-53-3 506-26-3 4184-93-4
DownStream 1
506-26-3

HS Code	2916190090
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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