2140-29-6

2140-29-6 structure

Name: Kojibiose
Chemical Name: kojibiose
CAS Number: 2140-29-6
Molecular Formula: C₁₂H₂₂O₁₁
Molecular Weight: 342.29600
Catalog: Research Areas Infection
Create Date: 2018-12-02 06:13:06
Modify Date: 2024-01-02 19:58:00
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].

Name	kojibiose
Synonyms	KOJIBIOSE Glc1-\|A-2Gal

Description	Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vivo	曲二糖 (0.5 %; w/w 每日摄入饮食; 持续 20 天) 显着改善花生酸 (ARa; 饮食每天 0.3 mg; 持续 20 天) 诱导的肝脏改变的严重程度[1]。 Animal Model: Female Wistar albino rats, aged 3 weeks with Streptozotocin (STZ; HY-13753) two doses of 25 mg/kg per d with a time lapse of 24 h[1] Dosage: 0.5%, w/w Administration: Diet; daily for 20 d Result: Significantly improved the severity of arachidic acid (ARa; 0.3 mg daily for 20 d)-induced hepatic alterations. Significantly increased expression values of PPAR α in comparison with those fed only ARa, suggesting an increased fatty acid metabolism. Showed reduced LPC and PS values than did animals fed only ARa.
References	[1]. José Moisés Laparra, et al. Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats. Br J Nutr. 2015 Nov 14;114(9):1395-402. [2]. Miaomiao Wang, et al. Cloning and expression of the sucrose phosphorylase gene in Bacillus subtilis and synthesis of kojibiose using the recombinant enzyme. Microb Cell Fact. 2018 Feb 15;17(1):23.

Density	1.68g/cm3
Boiling Point	783.7ºC at 760mmHg
Molecular Formula	C₁₂H₂₂O₁₁
Molecular Weight	342.29600
Flash Point	292.1ºC
Exact Mass	342.11600
PSA	189.53000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.652
Storage condition	-20°C

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3