107900-76-5

107900-76-5 structure

Name: Ganodermanondiol
Chemical Name: (5R,10S,13R,14R,17R)-17-[(2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
CAS Number: 107900-76-5
Molecular Formula: C₃₀H₄₈O₃
Molecular Weight: 456.700
Catalog: Natural product Moss
Create Date: 2018-08-16 09:56:47
Modify Date: 2024-01-19 20:09:33
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity[2]. Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM[3]. Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM[4].

Name	(5R,10S,13R,14R,17R)-17-[(2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonyms	( )-Ganodermanondiol Lanosta-7,9(11)-dien-3-one, 24,25-dihydroxy-, (24S)- Lanost-7,9(11)-dien-3-one-,24,25-dihydroxy-(24S) Lanosta-7,9(11)-dien-3-one,24,25-dihydroxy-,(24S) (24S)-24,25-Dihydroxylanosta-7,9(11)-dien-3-one Ganodermanondiol

Description	Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity[2]. Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM[3]. Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM[4].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 90μM (HIV-1 protease)[3]
References	[1]. Kim JW, et al. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int J Mol Sci. 2016 Oct 27;17(11). [2]. Li B, et al. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. Food Chem Toxicol. 2013 Mar;53:317-24. [3]. Min BS, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. [4]. Min BS, et al. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001 Dec;67(9):811-4.

Hazard Codes	Xi

7020-52-2

107900-76-5

Literature: Ruzicka; Denss; Jeger Helvetica Chimica Acta, 1946 , vol. 29, p. 204,207

60-29-7

7020-52-2

107900-76-5

Literature: Ruzicka; Denss; Jeger Helvetica Chimica Acta, 1946 , vol. 29, p. 204,207

Precursor 2
7020-52-2 60-29-7
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