60398-91-6

60398-91-6 structure

Name: Bufuralol hydrochloride
Chemical Name: (±)-Bufuralol hydrochloride
CAS Number: 60398-91-6
Molecular Formula: C₁₆H₂₄ClNO₂
Molecular Weight: 297.82000
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-06-24 05:35:11
Modify Date: 2024-01-06 12:20:26
Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].

Name	(±)-Bufuralol hydrochloride
Synonyms	1-(7-Ethyl-1-benzofuran-2-yl)-2-[(2-methyl-2-propanyl)amino]ethan ol hydrochloride (1:1)

Description	Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vitro	Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates[3].
In Vivo	Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers[4].
References	[1]. T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22(5):527-34. [2]. Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9. [3]. Sarah M Glass, et al. CYP2D6 Allelic Variants 34, 17-2, 17-3, and 53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46(8):1106-1117. [4]. T Prueksaritanont, et al. (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50(9):1521-5.

Boiling Point	393.2ºC at 760 mmHg
Melting Point	143-146ºC
Molecular Formula	C₁₆H₂₄ClNO₂
Molecular Weight	297.82000
Flash Point	191.6ºC
Exact Mass	297.15000
PSA	45.40000
LogP	4.60960

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport

Precursor 6
137740-36-4 18980-21-7 69543-78-8 85536-86-3
57704-12-8 137206-65-6
DownStream 0

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