1222781-70-5

1222781-70-5 structure

Name: ML133 HCl
Chemical Name: 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride
CAS Number: 1222781-70-5
Molecular Formula: C₁₉H₂₀ClNO
Molecular Weight: 313.82100
Catalog: Biochemical Inhibitor Transmembrane Transporters Potassium Channel Inhibitor
Create Date: 2016-04-05 01:52:51
Modify Date: 2024-01-02 21:19:07
ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

Name	1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride
Synonyms	N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride ML133 hydrochloride ML133 HCL 1-Naphthalenemethanamine (N-[(4-methoxyphenyl)methyl]

Description	ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].
References	[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%