| Name | 3,6,9-Trioxaundecanedioic acid |
|---|---|
| Synonyms |
2,2'-[Oxybis(2,1-ethanediyloxy)]diacetic acid
2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]acetic acid 2,2'-[Oxybis(ethane-2,1-diyloxy)]diacetic acid Acetic acid, 2,2'-[oxybis(2,1-ethanediyloxy)]bis- |
| Description | 369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 443.7±30.0 °C at 760 mmHg |
| Molecular Formula | C8H14O7 |
| Molecular Weight | 222.193 |
| Flash Point | 178.3±18.1 °C |
| Exact Mass | 222.073959 |
| PSA | 102.29000 |
| LogP | -1.96 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.474 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 41 |
| Safety Phrases | 26-39 |
| RIDADR | UN 1760 |
| Packaging Group | III |
| HS Code | 2918990090 |
|
~98%
13887-98-4 |
| Literature: Bright, Sandra A.; Brinko, Anne; Larsen, Maja Thim; Sinning, Steffen; Williams, D. Clive; Jensen, Henrik H. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1220 - 1224 |
|
~51%
13887-98-4 |
| Literature: Tetrahedron, , vol. 38, # 22 p. 3299 - 3308 |
|
~%
13887-98-4 |
| Literature: Tetrahedron, , vol. 38, # 14 p. 2055 - 2060 |
| Precursor 1 | |
|---|---|
| DownStream 4 | |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |