23243-68-7
23243-68-7 structure
- Name: 3,6-Dioxaoctanedioic acid
- Chemical Name: 2-[2-(carboxymethoxy)ethoxy]acetic acid
- CAS Number: 23243-68-7
- Molecular Formula: C6H10O6
- Molecular Weight: 178.14000
- Catalog: Chemical reagent Organic reagent fatty acid
- Create Date: 2018-06-30 09:41:23
- Modify Date: 2026-07-01 00:05:18
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36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-(carboxymethoxy)ethoxy]acetic acid |
|---|---|
| Synonyms |
DOODA
3,6-Dioxaoctanedioic acid CAS Acetic acid, 2,2'-[1,2-ethanediylbis(oxy)]bis- (Triglycolic acid) 2-[2-(Cboxymethyloxy)ethoxy]acetic acid 3,6-dioxaoctane-1,8-dioic acid (Ethylenebisoxy)diacetic acid 3,6-dioxoctanedioic acid 3,6-DIOXAOCTANEDIOIC ACID 3,6-dioxaoctadioic acid 3,6-Dioxaoctane-1,8-dioic acid 2,2'-[1,2-Ethanediylbis(oxy)]diacetic acid Acetic acid, 2,2‘-[1,2-ethanediylbis(oxy)]bis 2,2'-(ethane-1,2-diylbis(oxy))diacetic acid 3, 6-dioxyoctaneic acid PEG2-(CH2CO2H)2 (2-CBOXYMETHOXYETHOXY)ACETIC ACID 3,6-dioxa-1,8-octanedioic acid 1,2-Bis(cboxymethoxy)ethane 3,6-Dioxaoctandioic acid 2,5-Dioxa-1,6-hexanedicboxylic acid 3,6-Dioxasuberic acid 2,2'-(Ethylenebisoxy)diacetic acid 2,2'-[ethylenebis(oxy)] bisacetic acid HOOCCH2O-PEG1-CH2COOH (2-carboxymethoxyethoxy)acetic acid 2,2'-(Ethane-1,2-diylbis(oxy))diacetic acid 2,2'-[ethylenebis(oxy)]bisacetic acid HOOCCH2O-PEG1-CH2COOH/Acetic acid, 2,2'-[1,2-ethanediylbis(oxy)]bis 2-[2-(cboxymethoxy)ethoxy]aceticaci 2,2′-(Ethylenbis(oxy))bisessigsure 3,6-dioxaoctandioic acid |
| Description | 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.375g/cm3 |
|---|---|
| Boiling Point | 429.2ºC at 760mmHg |
| Melting Point | 68-71℃ |
| Molecular Formula | C6H10O6 |
| Molecular Weight | 178.14000 |
| Flash Point | 182.6ºC |
| Exact Mass | 178.04800 |
| PSA | 93.06000 |
| Vapour Pressure | 1.43E-08mmHg at 25°C |
| Index of Refraction | 1.474 |
| Storage condition | Store below +30°C. |
| Hazard Codes | C: Corrosive; |
|---|---|
| Risk Phrases | R34 |
| Safety Phrases | 26-36/37/39-45-27-22 |
| RIDADR | UN 3261 |
| Packaging Group | III |
| HS Code | 2918990090 |
|
~95%
23243-68-7 |
| Literature: Kuroboshi, Manabu; Yoshida, Tomonori; Oshitani, Jun; Goto, Kuniaki; Tanaka, Hideo Tetrahedron, 2009 , vol. 65, # 34 p. 7177 - 7185 |
|
~16%
23243-68-7 |
| Literature: Tetrahedron, , vol. 38, # 22 p. 3299 - 3308 |
| Precursor 2 | |
|---|---|
| DownStream 4 | |
![2-[2-(2-chloro-2-oxoethoxy)ethoxy]acetyl chloride structure](https://image.chemsrc.com/caspic/374/31255-09-1.png)
![2-[2-[2-(dioctadecylamino)-2-oxoethoxy]ethoxy]-N,N-dipropylacetamide structure](https://image.chemsrc.com/caspic/322/72469-41-1.png)
![2-[2-[2-(dipropylamino)-2-oxoethoxy]ethoxy]-N,N-dipropylacetamide structure](https://image.chemsrc.com/caspic/087/58774-46-2.png)
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |