453590-24-4

453590-24-4 structure

Name: TIE-2/VEGFR-2 kinase-IN-1
Chemical Name: 6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine
CAS Number: 453590-24-4
Molecular Formula: C₁₃H₁₁N₃O₂
Molecular Weight: 241.24500
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2018-11-29 05:28:13
Modify Date: 2024-01-10 10:43:02
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].

Name	6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine
Synonyms	hms3303n07

Description	TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
In Vitro	Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1]. Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.
References	[1]. Jerry Leroy Adams, et al. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors. Patent WO2003022852.

77287-34-4

26454-83-1

~66%

453590-24-4

Literature: SMITHKLINE BEECHAM CORPORATION Patent: WO2005/61516 A1, 2005 ; Location in patent: Page/Page column 17-19 ; WO 2005/061516 A1

2632-13-5

453590-24-4

26454-79-5

453590-24-4

Precursor 4
77287-34-4 26454-83-1 2632-13-5 26454-79-5
DownStream 0