TIE-2/VEGFR-2 kinase-IN-1
Modify Date: 2024-01-10 10:43:02
TIE-2/VEGFR-2 kinase-IN-1 structure
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Common Name | TIE-2/VEGFR-2 kinase-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 453590-24-4 | Molecular Weight | 241.24500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H11N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TIE-2/VEGFR-2 kinase-IN-1TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1]. |
| Name | 6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine |
|---|---|
| Synonym | More Synonyms |
| Description | TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1]. |
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| Related Catalog | |
| In Vitro | Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1]. Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis. |
| References |
| Molecular Formula | C13H11N3O2 |
|---|---|
| Molecular Weight | 241.24500 |
| Exact Mass | 241.08500 |
| PSA | 74.17000 |
| LogP | 3.06180 |
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~66%
TIE-2/VEGFR-2 k... CAS#:453590-24-4 |
| Literature: SMITHKLINE BEECHAM CORPORATION Patent: WO2005/61516 A1, 2005 ; Location in patent: Page/Page column 17-19 ; WO 2005/061516 A1 |
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~%
TIE-2/VEGFR-2 k... CAS#:453590-24-4 |
| Literature: Miyazaki, Yasushi; Matsunaga, Shinichiro; Tang, Jun; Maeda, Yutaka; Nakano, Masato; Philippe, Rocher J.; Shibahara, Megumi; Liu, Wei; Sato, Hideyuki; Wang, Liping; Nolte, Robert T. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2203 - 2207 |
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~%
TIE-2/VEGFR-2 k... CAS#:453590-24-4 |
| Literature: Miyazaki, Yasushi; Matsunaga, Shinichiro; Tang, Jun; Maeda, Yutaka; Nakano, Masato; Philippe, Rocher J.; Shibahara, Megumi; Liu, Wei; Sato, Hideyuki; Wang, Liping; Nolte, Robert T. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2203 - 2207 |
| hms3303n07 |