Name | 4-Methylpyrazole hydrochloride |
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Synonyms |
Fomepizole Hydrochloride
MFCD00012707 4-methyl-1H-pyrazole,hydrochloride |
Description | Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. |
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Related Catalog | |
Target |
CYP2E1 |
In Vivo | Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4] Animal Model: Male CD-1 mice weighing 18-25 g[4] Dosage: 25 mg/kg Administration: IP; single dose Result: Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50). |
References |
[1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. |
Melting Point | 157-159 °C |
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Molecular Formula | C4H7ClN2 |
Molecular Weight | 118.56500 |
Exact Mass | 118.03000 |
PSA | 28.68000 |
LogP | 1.52010 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi |
Risk Phrases | 36/37/38 |
Safety Phrases | 26-36 |
RIDADR | NONH for all modes of transport |
HS Code | 2933199090 |
HS Code | 2933199090 |
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Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |