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99217-63-7

99217-63-7 structure
99217-63-7 structure
  • Name: Kushenol A
  • Chemical Name: Kushenol A
  • CAS Number: 99217-63-7
  • Molecular Formula: C25H28O5
  • Molecular Weight: 408.487
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-10-13 21:08:25
  • Modify Date: 2025-08-25 22:31:19
  • Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

Name Kushenol A
Synonyms (2S)-5,7-Dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
Description Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
Related Catalog
References

[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054.

[2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.

Density 1.2±0.1 g/cm3
Boiling Point 581.7±50.0 °C at 760 mmHg
Molecular Formula C25H28O5
Molecular Weight 408.487
Flash Point 195.8±23.6 °C
Exact Mass 408.193665
PSA 86.99000
LogP 7.24
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.607
Storage condition 2-8℃
Hazard Codes Xi
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