161068-53-7
161068-53-7 structure
- Name: Epimedokoreanin B
- Chemical Name: Epimedokoreanin B
- CAS Number: 161068-53-7
- Molecular Formula: C25H26O6
- Molecular Weight: 422.470
- Catalog: Natural product Flavonoids
- Create Date: 2016-10-13 16:50:02
- Modify Date: 2024-01-02 15:20:00
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Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated Apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3].
| Name | Epimedokoreanin B |
|---|---|
| Synonyms |
2-(3,4-Dihydroxy-5-((E)-3-methyl-but-2-enyl)-phenyl)-5,7-dihydroxy-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one
2-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-4H-chromen-4-one 2-[3,4-Dihydroxy-5-((E)-3-methyl-but-2-enyl)-phenyl]-5,7-dihydroxy-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 2-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)- |
| Description | Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated Apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Epimedokoreanin B (compound6; 3.13-25 μM; 48 hours) 对肺癌细胞 A549、Calu1 和 H1299 的增殖显示出显着的抑制作用。Epimedokoreanin B 对人支气管上皮细胞 BEAS-2B 无毒性[1]。 Epimedokoreanin B 处理抑制 A549 和 NCI-H292 细胞中伴随细胞质空泡形成的细胞增殖和迁移。Epimedokoreanin B 处理的细胞中观察到自噬体聚集并伴有自噬通量阻断，这与内质网应激的发生相符[2]。 Epimedokoreanin B（5 μM；24 小时）抑制 CD163 表达和 IL-10 的产生，这是已知的 M2 标记，表明 Epimedokoreanin B 抑制人单核细胞衍生巨噬细胞 (HMDM) 中的 M2 极化。Epimedokoreanin B 抑制 HMDMs 中的 STAT3 激活[4]。 Cell Cytotoxicity Assay[1] Cell Line: A549, Calu1 and H1299 cells Concentration: 3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time: 48 hours Result: Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299. Western Blot Analysis[4] Cell Line: Human monocyte-derived macrophages (HMDMs) Concentration: 5 μM Incubation Time: 24 hours Result: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299. |
| In Vivo | Epimedokoreanin B（20 mg/kg；口服；每周三次；持续 17 天）抑制 LM8 荷瘤鼠模型中的肿瘤生长[4]。 Animal Model: Female C3H mice (8-10 weeks old) injected with LM8 cells[4] Dosage: 20 mg/kg Administration: Oral administration; thrice a week; for 17 days Result: Inhibited tumor growth. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 665.9±55.0 °C at 760 mmHg |
| Molecular Formula | C25H26O6 |
| Molecular Weight | 422.470 |
| Flash Point | 228.2±25.0 °C |
| Exact Mass | 422.172943 |
| PSA | 111.13000 |
| LogP | 6.59 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.650 |