845861-49-6

845861-49-6 structure

845861-49-6 structure

Name: 2-Methyl-5-HT hydrochloride
Chemical Name: 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
CAS Number: 845861-49-6
Molecular Formula: C₁₁H₁₅ClN₂O
Molecular Weight: 226.70300
Create Date: 2016-10-08 00:49:38
Modify Date: 2024-02-08 21:49:39
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

Name	3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
Synonyms	2-Methylserotonin.HCl

Description	2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].
Target	5-HT3 Receptor
In Vivo	2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References	[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

Molecular Formula	C₁₁H₁₅ClN₂O
Molecular Weight	226.70300
Exact Mass	226.08700
PSA	62.04000
LogP	3.18540

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%