845861-49-6

845861-49-6 structure
845861-49-6 structure
  • Name: 2-Methyl-5-HT hydrochloride
  • Chemical Name: 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
  • CAS Number: 845861-49-6
  • Molecular Formula: C11H15ClN2O
  • Molecular Weight: 226.70300
  • Create Date: 2016-10-08 00:49:38
  • Modify Date: 2024-02-08 21:49:39
  • 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

Name 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
Synonyms 2-Methylserotonin.HCl
Description 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].
Target

5-HT3 Receptor

In Vivo 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

Molecular Formula C11H15ClN2O
Molecular Weight 226.70300
Exact Mass 226.08700
PSA 62.04000
LogP 3.18540
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%