2-Methyl-5-HT hydrochloride

Modify Date: 2024-02-08 21:49:39

2-Methyl-5-HT hydrochloride Structure
2-Methyl-5-HT hydrochloride structure
Common Name 2-Methyl-5-HT hydrochloride
CAS Number 845861-49-6 Molecular Weight 226.70300
Density N/A Boiling Point N/A
Molecular Formula C11H15ClN2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-Methyl-5-HT hydrochloride


2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

 Names

Name 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
Synonym More Synonyms

 2-Methyl-5-HT hydrochloride Biological Activity

Description 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].
Target

5-HT3 Receptor

In Vivo 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

 Chemical & Physical Properties

Molecular Formula C11H15ClN2O
Molecular Weight 226.70300
Exact Mass 226.08700
PSA 62.04000
LogP 3.18540

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Methylserotonin.HCl