13616-29-0
13616-29-0 structure
- Name: GSK837149A
- Chemical Name: N,N'-bis-(4-methyl-pyrimidin-2-yl)-4,4'-carbonyldiamino-bis-benzenesulfonamide
- CAS Number: 13616-29-0
- Molecular Formula: C23H22N8O5S2
- Molecular Weight: 554.60100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Fatty Acid Synthase (FAS)
- Create Date: 2017-12-21 01:13:35
- Modify Date: 2024-01-11 00:28:08
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GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2].
| Name | N,N'-bis-(4-methyl-pyrimidin-2-yl)-4,4'-carbonyldiamino-bis-benzenesulfonamide |
|---|---|
| Synonyms | N,N'-Di[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)phenyl]-urea |
| Description | GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 30 nM (type I FASN)[1] |
| In Vitro | GSK837149A (0.1 nM-0.1 mM) 对乙酰辅酶 A/丙二酰辅酶 A 和乙酰乙酰辅酶 A 的抑制作用随作用浓度增加而增强[1]。 |
| References |
| Molecular Formula | C23H22N8O5S2 |
|---|---|
| Molecular Weight | 554.60100 |
| Exact Mass | 554.11500 |
| PSA | 201.79000 |
| LogP | 5.58260 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |