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2898-95-5

2898-95-5 structure
2898-95-5 structure
  • Name: Ursodeoxycholic acid sodium
  • Chemical Name: NaUDCh
  • CAS Number: 2898-95-5
  • Molecular Formula: C24H39NaO4
  • Molecular Weight: 414.554
  • Catalog: Signaling Pathways GPCR/G Protein GPCR19
  • Create Date: 2017-12-30 12:00:17
  • Modify Date: 2024-01-07 09:29:04
  • Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

Name NaUDCh
Synonyms Cholan-24-oic acid, 3,7-dihydroxy-, monosodium salt, (3α,5β,7β)-
SODIUM URSODEOXYCHOLATE HYDRATE
Cholan-24-oic acid, 3,7-dihydroxy-, sodium salt, (3α,5β,7β)- (1:1)
Sodium (3α,5β,7β)-3,7-dihydroxycholan-24-oate
Ursodeoxycholic Acid (sodium salt)
Description Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].
Related Catalog
Target

Microbial Metabolite

In Vivo Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) sodium results in weight loss in C57BL/6J wildtype mice[1]. Animal Model: 5 week old C57BL/6J WT mice (male and female)[1] Dosage: 50, 150, and 450 mg/kg dissolved in corn oil Administration: Oral gavage; daily for 21 days Result: Mice in the 50 and 450 mg/kg groups sustained significant weight loss within a week. At 50 mg/kg, this weight loss persisted over the course of the experiment. At 450 mg/kg, initially weight loss was noted during the first and third week of ursodiol administration. At 150 mg/kg, it did not have significantly different weights compared to the untreated mice.
References

[1]. Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16(2):e0246161. Published 2021 Feb 18.

[2]. Goossens JF, et al. Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396.

Molecular Formula C24H39NaO4
Molecular Weight 414.554
Exact Mass 414.274597
PSA 80.59000
LogP 3.14320
Vapour Pressure 2.98E-14mmHg at 25°C