Top Suppliers:I want be here
Related CAS#:
547-32-0 1392514-03-2
61538-65-6 9003-59-2
54600-91-8 30605-57-3
12558-49-5 518-47-8
94313-96-9 1345-00-2
2415535-24-7 2415542-19-5
2415632-15-2 2327223-01-6
2415601-65-7 2415526-13-3
2415520-18-0 2415520-95-3
2415622-18-1 2415569-34-3

547-32-0

547-32-0 structure
547-32-0 structure
  • Name: Sulfadiazine sodium
  • Chemical Name: Sulfadiazine sodium salt
  • CAS Number: 547-32-0
  • Molecular Formula: C10H9N4NaO2S
  • Molecular Weight: 272.259
  • Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2024-01-02 17:27:29
  • Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis[1][2].
Name Sulfadiazine sodium salt
Synonyms sulfadiazine sodium
MFCD00067333
Sodium [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide
Sodium sulfadiazine
Sulphadiazine sodium
Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, sodium salt (1:1)
sodium,(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
EINECS 208-919-0
sodium [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide
Description Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis[1][2].
Related Catalog
In Vivo In this study, the effectiveness of Sulfadiazine sodium and Pyrimetamine for the treatment of mice during acute infection with different atypical T. gondii strains was evaluated. Swiss mice were infected with seven T. gondii strainsl. The infected mice were treated with 10-640 mg/kg per day of Sulfadiazine sodium, 3-200 mg/kg per day of Pyrimetamine, or a combination of both drugs with a lower dosage. A descriptive analysis was used to assess the association between susceptibility to sodium and/or Pyrimetamine and the genotype. The TgCTBr4 and TgCTBr17 strains (genotype 108) presented lower susceptibility to sodium or Pyrimetamine treatment. The TgCTBr1 and TgCTBr25 strains (genotype 206) presented similar susceptibility to PYR but not sodium treatment. The TgCTBr9 strain (genotype 11) was the only strain with high susceptibility to treatment with both drugs [1].
References

[1]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013 Jan;83(1):125-34.

[2]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019 Jul;202:7-14.
Density 1.496g/cm3
Boiling Point 512.6ºC at 760 mmHg
Molecular Formula C10H9N4NaO2S
Molecular Weight 272.259
Flash Point 263.8ºC
Exact Mass 272.034393
PSA 97.56000
LogP 2.38040
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP2000000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosodium salt
CAS REGISTRY NUMBER :
547-32-0
LAST UPDATED :
199304
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H9-N4-O2-S.Na
MOLECULAR WEIGHT :
272.28
WISWESSER LINE NOTATION :
T6N CNJ BMSWR DZ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1747 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1408 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 142,64,1943
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1440 mg/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 101,362,1951
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Multiple routes
DOSE :
2400 mg/kg
SEX/DURATION :
female 6-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 101,362,1951
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H315-H317-H319-H334-H335
Precautionary Statements P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn
Risk Phrases 22-36/37/38-42/43
Safety Phrases 22-26-36/37-45
RIDADR 3249
WGK Germany 3
RTECS WP2000000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2935009090
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:547-32-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 547-32-0 | Chemsrc address: https://m.chemsrc.com/en/baike/663362.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved