533-75-5

533-75-5 structure

Name: Tropolone
Chemical Name: Tropolone
CAS Number: 533-75-5
Molecular Formula: C₇H₆O₂
Molecular Weight: 122.121
Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
Create Date: 2018-02-14 08:00:00
Modify Date: 2026-07-02 09:38:55
Tropolone, a tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate[1]. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU2+[2].

Name	Tropolone
Synonyms	Tropolone, R 2,4,6-Cyclohtatrien-1-one, 2-hydroxy 2-Hydroxy-2,4,6-Cyclohtatrie 6-cyclohtatrien-1-one,2-hydroxy-4 2-hydroxytropone EINECS 208-577-2 Tropolone(8CI) Tropolone, 10 mM in DMSO 2-Hydroxy-2,4,6-cyclohtatriene-1-one a-Tropolone 2-hydroxycyclohepta-2,4,6-trienone TROPOLONE FOR SYNTHESIS 1 G 2-Hydroxycyclohta-2,4,6-trien-1-one 2-Hydroxy-2,4,6-cycloheptatrien-1-one 2-hydroxycyclohepta-2,4,6-trien-1-one Tropolone , >= 2-HYDROXY-2,4,6-CYCLOHTATRIENONE 2-Hydroxy-2,4,6-cycloheptatrienone 2-hydroxy-2,4,6-cycloheptatriene-1-one SKL248 Purpurocatechol 2-Hydroxycyclohta-2,4,6-trienone Tropolone (Assay) 2-hydroxi-2,4,6-cycloheptatrien-1-one Tropolone -5 TROPOLONE TropoL TROPOLONE FOR SYNTHESIS 5 G Phenylethylamine hydrochloride 2-HYDROXY-2,4,6-CYCLOHTATRIEN-1-ONE Tropolone > aminoethylbenzene hydrochloride 2-Hydroxycyclohtane-2,4,6-triene-1-one MFCD00004158

Description	Tropolone, a tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate[1]. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU2+[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
Target	IC50: 0.4 μM (mushroom tyrosinase)[2]
References	[1]. Donald D Nolting,et al. Synthesis of bicyclo[5.3.0]azulene derivatives. Nat Protoc. 2009; 4(8): 1113–1117. [2]. VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 14,217,1979

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 14,217,1979

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,550,1971

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 92,19,1972

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU4075000
HS Code	29144090

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%