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  • Product Name: Fexofenadine
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83799-24-0

83799-24-0 structure
83799-24-0 structure
  • Name: Fexofenadine
  • Chemical Name: fexofenadine
  • CAS Number: 83799-24-0
  • Molecular Formula: C32H39NO4
  • Molecular Weight: 501.656
  • Catalog: API Antiallergic Antihistamine
  • Create Date: 2018-07-16 19:41:12
  • Modify Date: 2024-01-02 17:25:13
  • Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].
Name fexofenadine
Synonyms 4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid
Fexofenadine-D5
Fexafenadine
2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)phenyl)-2-methylpropionic acid
CARBOXYTERFENADINE
Fexofenadine
benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-
Terfenadine acid
TERFENADINECARBOXYLATE
Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-
Telfast
MFCD00871892
2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid
2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid
Fexofenadinebase
Description Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].
Related Catalog
Target

H1 Receptor
In Vitro Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2]. Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2]. Western Blot Analysis[2] Cell Line: Nasal fibroblasts Concentration: 100 μM Incubation Time: 1 hour Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.
In Vivo Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1]. Animal Model: C57BL/6 mice infected with Trichinella spiralis[1] Dosage: 5, 10 and 20 mg/kg Administration: Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result: Inhibited eosinophilia in a dose-dependent manner. Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
Density 1.2±0.1 g/cm3
Boiling Point 697.3±55.0 °C at 760 mmHg
Melting Point 218-220ºC
Molecular Formula C32H39NO4
Molecular Weight 501.656
Flash Point 375.5±31.5 °C
Exact Mass 501.287903
PSA 81.00000
LogP 4.80
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.597
Storage condition -20°C Freezer
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 83799-24-0 | Chemsrc address: https://m.chemsrc.com/en/baike/667418.html

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