Fexofenadine
Modify Date: 2024-01-02 17:25:13
Fexofenadine structure
|
Common Name | Fexofenadine | ||
|---|---|---|---|---|
| CAS Number | 83799-24-0 | Molecular Weight | 501.656 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 697.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C32H39NO4 | Melting Point | 218-220ºC | |
| MSDS | N/A | Flash Point | 375.5±31.5 °C | |
Use of FexofenadineFexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3]. |
| Name | fexofenadine |
|---|---|
| Synonym | More Synonyms |
| Description | Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
H1 Receptor |
| In Vitro | Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2]. Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2]. Western Blot Analysis[2] Cell Line: Nasal fibroblasts Concentration: 100 μM Incubation Time: 1 hour Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway. |
| In Vivo | Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1]. Animal Model: C57BL/6 mice infected with Trichinella spiralis[1] Dosage: 5, 10 and 20 mg/kg Administration: Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result: Inhibited eosinophilia in a dose-dependent manner. Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 697.3±55.0 °C at 760 mmHg |
| Melting Point | 218-220ºC |
| Molecular Formula | C32H39NO4 |
| Molecular Weight | 501.656 |
| Flash Point | 375.5±31.5 °C |
| Exact Mass | 501.287903 |
| PSA | 81.00000 |
| LogP | 4.80 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.597 |
| Storage condition | -20°C Freezer |
| HS Code | 2933399090 |
|---|
CAS#:76811-98-8
CAS#:154477-55-1
CAS#:115-46-8
CAS#:50679-08-8
CAS#:154825-96-4
CAS#:138452-21-8| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid |
| Fexofenadine-D5 |
| Fexafenadine |
| 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)phenyl)-2-methylpropionic acid |
| CARBOXYTERFENADINE |
| Fexofenadine |
| benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl- |
| Terfenadine acid |
| TERFENADINECARBOXYLATE |
| Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl- |
| Telfast |
| MFCD00871892 |
| 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid |
| 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid |
| Fexofenadinebase |
- DC Chemicals Limited
- China
- Product Name: Fexofenadine
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Fexofenadine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Xi'an Reach Pharmaceutical Technology Co.,Ltd.
- China
- Product Name: Fex 12
- Price: ￥Inquiry/1kg
- Purity: 96.0%
- Stocking Period: Inquiry
- Contact: Grace
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: TIANU-CHEM_Fexofenadine 83799-24-0
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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