CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TZ3699000
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CHEMICAL NAME :
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Propane, 1,2-epoxy-3-(tolyloxy)-
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CAS REGISTRY NUMBER :
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26447-14-3
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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13
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MOLECULAR FORMULA :
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C10-H12-O2
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MOLECULAR WEIGHT :
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164.22
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5140 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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282 mg/m3
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1700 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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310 mg/m3
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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2 mL/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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1650 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Yeast - Saccharomyces cerevisiae
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DOSE/DURATION :
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1 mg/plate
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REFERENCE :
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TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206476 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0038 No. of Facilities: 63 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 524 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0038 No. of Facilities: 119 (estimated) No. of Industries: 10 No. of Occupations: 11 No. of Employees: 4507 (estimated) No. of Female Employees: 1696 (estimated)
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