1772-39-0

1772-39-0 structure

Name: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
Chemical Name: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
CAS Number: 1772-39-0
Molecular Formula: C₁₃H₈N₄O₄
Molecular Weight: 284.22700
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2018-12-03 14:46:32
Modify Date: 2024-01-26 17:35:16
MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].

Name	6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
Synonyms	5-nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazole 5-nitro-2-(4-nitro-phenyl)-1(3)H-benzoimidazole 5-Nitro-2-(4-nitro-phenyl)-1H-benzoimidazole 2-(4-nitrophenyl)-5-nitro-1H-benzimidazole 5-Nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazol 5-nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole 2-(4-nitrophenyl)-5-nitrobenzimidazole 5-nitro-2-(4-nitrophenyl)-1H-benzimidazole

Description	MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-2:4.2 ± 0.2 μM (IC50) MMP13:12 ± 7 μM (IC50) MMP-9:23.3 ± 10. μM (IC50) MMP-8:25 ± 10 μM (IC50)
References	[1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.

HS Code	2933990090

Precursor 0
DownStream 2
71002-88-5 7621-86-5

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%