1772-39-0

1772-39-0 structure
1772-39-0 structure
  • Name: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
  • Chemical Name: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
  • CAS Number: 1772-39-0
  • Molecular Formula: C13H8N4O4
  • Molecular Weight: 284.22700
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
  • Create Date: 2018-12-03 14:46:32
  • Modify Date: 2024-01-26 17:35:16
  • MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].

Name 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
Synonyms 5-nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazole
5-nitro-2-(4-nitro-phenyl)-1(3)H-benzoimidazole
5-Nitro-2-(4-nitro-phenyl)-1H-benzoimidazole
2-(4-nitrophenyl)-5-nitro-1H-benzimidazole
5-Nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazol
5-nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole
2-(4-nitrophenyl)-5-nitrobenzimidazole
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole
Description MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].
Related Catalog
Target

MMP-2:4.2 ± 0.2 μM (IC50)

MMP13:12 ± 7 μM (IC50)

MMP-9:23.3 ± 10. μM (IC50)

MMP-8:25 ± 10 μM (IC50)

References

[1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.

Density 1.544g/cm3
Boiling Point 565.2ºC at 760mmHg
Molecular Formula C13H8N4O4
Molecular Weight 284.22700
Flash Point 295.6ºC
Exact Mass 284.05500
PSA 120.32000
LogP 4.09270
Vapour Pressure 8.54E-13mmHg at 25°C
Index of Refraction 1.74
HS Code 2933990090
Precursor  0

DownStream  2

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%