76081-98-6

76081-98-6 structure

Name: SCH 28080
Chemical Name: 2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile
CAS Number: 76081-98-6
Molecular Formula: C₁₇H₁₅N₃O
Molecular Weight: 277.32
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Proton Pump
Create Date: 2016-07-06 12:18:39
Modify Date: 2024-01-09 19:35:24
SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes[1]. Antisecretory and cytoprotective activities[2].

Name	2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile
Synonyms	MFCD00834620

Description	SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes[1]. Antisecretory and cytoprotective activities[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
Target	IC50: 20 nM (H+/K+-ATPase, rabbit microsomal membranes)[1]
References	[1]. Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36(1):97-104. [2]. Long JF, et al. Gastric antisecretory and cytoprotective activities of SCH 28080. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

24016-03-3

79707-09-8

76081-98-6

79707-50-9

76081-98-6

Literature: Schering Corporation Patent: US4450164 A1, 1984 ;

79707-49-6

76081-98-6

Literature: Schering Corporation Patent: US4450164 A1, 1984 ;

143-33-9

79707-59-8

~67%

76081-98-6

927-56-0

76081-98-6

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%