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39025-23-5

39025-23-5 structure
39025-23-5 structure
  • Name: Z-Guggulsterone
  • Chemical Name: (Z)-Guggulsterone
  • CAS Number: 39025-23-5
  • Molecular Formula: C21H28O2
  • Molecular Weight: 312.446
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-09-05 11:10:03
  • Modify Date: 2024-01-06 16:45:54
  • Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].

Name (Z)-Guggulsterone
Synonyms Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione
(17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione
UNII:9B259YE66O
Pregna-4,17(20)-diene-3,16-dione, (17E)-
(17E)-Pregna-4,17(20)-diene-3,16-dione
Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione
E-guggulsterone
Pregna-4,17-diene-3,16-dione, (17E)-
trans-Guggulsterone
GUGGULSTERONE, (E)-
Description Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].
Related Catalog
Target

VEGF-R2

Akt

In Vitro Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC.
In Vivo Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1]. Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage: 1 mg Administration: Oral; 5 times/week Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
References

[1]. Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.

Density 1.1±0.1 g/cm3
Boiling Point 463.3±45.0 °C at 760 mmHg
Melting Point 188-190°
Molecular Formula C21H28O2
Molecular Weight 312.446
Flash Point 172.3±25.7 °C
Exact Mass 312.208923
PSA 34.14000
LogP 3.65
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.557
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R37
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
Precursor  1

DownStream  0