39025-23-5

39025-23-5 structure

Name: Z-Guggulsterone
Chemical Name: (Z)-Guggulsterone
CAS Number: 39025-23-5
Molecular Formula: C₂₁H₂₈O₂
Molecular Weight: 312.446
Catalog: Biochemical Plant extracts
Create Date: 2018-09-05 11:10:03
Modify Date: 2024-01-06 16:45:54
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].

Name	(Z)-Guggulsterone
Synonyms	Guggulsterone (17E)-Pregna-4,17-diene-3,16-dione (17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione UNII:9B259YE66O Pregna-4,17(20)-diene-3,16-dione, (17E)- (17E)-Pregna-4,17(20)-diene-3,16-dione Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione E-guggulsterone Pregna-4,17-diene-3,16-dione, (17E)- trans-Guggulsterone GUGGULSTERONE, (E)-

Description	Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGF-R2 Akt
In Vitro	Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC.
In Vivo	Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1]. Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage: 1 mg Administration: Oral; 5 times/week Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
References	[1]. Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R37
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 1
3347-58-8
DownStream 0