Name | sfllrnpndkyepf |
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Synonyms |
MFCD00133815
Thrombin Receptor Activator Ser-phe-leu-leu-arg-asn-pro-asn-asp-lys-tyr-glu-pro-phe TRAP Thrombin Receptor Agonist Peptide Thrombin Receptor Activator Peptide Thrombin receptor agonist peptide-14 TRAP-14 |
Description | SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide. |
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Related Catalog | |
In Vitro | Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3]. |
References |
Molecular Formula | C81H118N20O23 |
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Molecular Weight | 1739.92000 |
Exact Mass | 1738.87000 |
PSA | 713.20000 |
LogP | 2.88170 |
Storage condition | −20°C |