TRAP-14 trifluoroacetate salt

Modify Date: 2024-01-02 19:55:03

TRAP-14 trifluoroacetate salt structure	Common Name	TRAP-14 trifluoroacetate salt
	CAS Number	137339-65-2	Molecular Weight	1739.92000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₁H₁₁₈N₂₀O₂₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of TRAP-14 trifluoroacetate salt

SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

Name	sfllrnpndkyepf
Synonym	More Synonyms

Description	SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease
In Vitro	Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].
References	[1]. Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9. [2]. Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10. [3]. Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9.

Molecular Formula	C₈₁H₁₁₈N₂₀O₂₃
Molecular Weight	1739.92000
Exact Mass	1738.87000
PSA	713.20000
LogP	2.88170
Storage condition	−20°C

TRAP-14 trifluoroacetate salt MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T
Risk Phrases	61
Safety Phrases	53-45
RIDADR	NONH for all modes of transport
WGK Germany	3

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MFCD00133815

Thrombin Receptor Activator

Ser-phe-leu-leu-arg-asn-pro-asn-asp-lys-tyr-glu-pro-phe

TRAP

Thrombin Receptor Agonist Peptide

Thrombin Receptor Activator Peptide

Thrombin receptor agonist peptide-14

TRAP-14