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117399-94-7

117399-94-7 structure
117399-94-7 structure
  • Name: Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt
  • Chemical Name: Endothelin 1
  • CAS Number: 117399-94-7
  • Molecular Formula: C109H159N25O32S5
  • Molecular Weight: 2491.902
  • Catalog: Biochemical Peptide
  • Create Date: 2018-05-03 08:00:00
  • Modify Date: 2024-01-02 17:43:01
  • Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

Name Endothelin 1
Synonyms MFCD00133305
CSCSSLMDKECVYFCHLDIIW
Endothelin 1 (swine, human)
Description Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.
Related Catalog
Target

ETA and ETB[1]

In Vitro Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].
References

[1]. Kowalczyk A, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response andsepsis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52.

Density 1.3±0.1 g/cm3
Boiling Point 2467.3±65.0 °C at 760 mmHg
Molecular Formula C109H159N25O32S5
Molecular Weight 2491.902
Flash Point 1446.0±34.3 °C
Exact Mass 2490.018555
PSA 1035.13000
LogP -0.36
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.556
Storage condition −20°C
Water Solubility 1% acetic acid: >1 mg/mL | Soluble in water.
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+
RIDADR 2811.0
WGK Germany 3
RTECS KE9446500
Hazard Class 6.1