117399-94-7

117399-94-7 structure

Name: Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt
Chemical Name: Endothelin 1
CAS Number: 117399-94-7
Molecular Formula: C₁₀₉H₁₅₉N₂₅O₃₂S₅
Molecular Weight: 2491.902
Catalog: Biochemical Peptide
Create Date: 2018-05-03 08:00:00
Modify Date: 2025-08-21 11:43:53
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

Name	Endothelin 1
Synonyms	MFCD00133305 CSCSSLMDKECVYFCHLDIIW Endothelin 1 (swine, human)

Description	Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Peptides Research Areas >> Inflammation/Immunology
Target	ETA and ETB[1]
In Vitro	Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].
References	[1]. Kowalczyk A, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response andsepsis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52.

Density	1.3±0.1 g/cm3
Boiling Point	2467.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Molecular Weight	2491.902
Flash Point	1446.0±34.3 °C
Exact Mass	2490.018555
PSA	1035.13000
LogP	-0.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.556
Storage condition	−20°C
Water Solubility	1% acetic acid: >1 mg/mL \| Soluble in water.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
RIDADR	2811.0
WGK Germany	3
RTECS	KE9446500
Hazard Class	6.1