| Name | Endothelin 1 |
|---|---|
| Synonyms |
MFCD00133305
CSCSSLMDKECVYFCHLDIIW Endothelin 1 (swine, human) |
| Description | Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB. |
|---|---|
| Related Catalog | |
| Target |
ETA and ETB[1] |
| In Vitro | Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 2467.3±65.0 °C at 760 mmHg |
| Molecular Formula | C109H159N25O32S5 |
| Molecular Weight | 2491.902 |
| Flash Point | 1446.0±34.3 °C |
| Exact Mass | 2490.018555 |
| PSA | 1035.13000 |
| LogP | -0.36 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.556 |
| Storage condition | −20°C |
| Water Solubility | 1% acetic acid: >1 mg/mL | Soluble in water. |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | T+ |
| RIDADR | 2811.0 |
| WGK Germany | 3 |
| RTECS | KE9446500 |
| Hazard Class | 6.1 |