Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt

Modify Date: 2024-01-02 17:43:01

Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt structure	Common Name	Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt
	CAS Number	117399-94-7	Molecular Weight	2491.902
	Density	1.3±0.1 g/cm3	Boiling Point	2467.3±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	1446.0±34.3 °C

Use of Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt

Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

Name	Endothelin 1
Synonym	More Synonyms

Description	Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Peptides Research Areas >> Inflammation/Immunology
Target	ETA and ETB[1]
In Vitro	Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].
References	[1]. Kowalczyk A, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response andsepsis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52.

Density	1.3±0.1 g/cm3
Boiling Point	2467.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Molecular Weight	2491.902
Flash Point	1446.0±34.3 °C
Exact Mass	2490.018555
PSA	1035.13000
LogP	-0.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.556
Storage condition	−20°C
Water Solubility	1% acetic acid: >1 mg/mL \| Soluble in water.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
RIDADR	2811.0
WGK Germany	3
RTECS	KE9446500
Hazard Class	6.1

ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.

Biochem. Pharmacol. 90(4) , 406-13, (2014)

Endothelin-1 (ET-1) induces lipolysis in adipocytes, where ET-1 chronic exposure results in insulin resistance (IR) through suppression of glucose transporter (GLUT)4 translocation to the plasma membr...

HJP272, a novel endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury in hamsters.

Lung 192(5) , 803-10, (2014)

Previous studies from this laboratory indicate that endothelin-1 (ET-1), a potent vasoconstrictor, may play an important role in lipopolysaccharide (LPS)-induced release of neutrophils from the pulmon...

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.

Biochem. Pharmacol. 94(2) , 91-100, (2015)

Important structural differences imply that human and mouse mast cell chymases may differ with respect to their enzymatic properties. We compared in this study the catalytic efficiencies of recombinan...

MFCD00133305

CSCSSLMDKECVYFCHLDIIW

Endothelin 1 (swine, human)