Name | ionomycin |
---|---|
Synonyms |
10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadienoic acid Ionomycin Ionomycin free acid,(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid Ionomycin,Free Acid,from Streptomyces conglbatus MFCD00036890 Ionomycinefreeacid Ionomycin from Streptomyces conglobatus IONOMYCIN,STREPTOMYCES CONGLOBATUS (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid Ionomycin free acid Ionomycin,Free Acid,Streptomyces conglobatus |
Description | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005. |
---|---|
Related Catalog | |
Target |
Calcium channel[1]. |
In Vitro | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005[1]. It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2]. |
References |
Density | 1.072 g/cm3 |
---|---|
Boiling Point | 817.2ºC at 760 mmHg |
Molecular Formula | C41H72O9 |
Molecular Weight | 709.00500 |
Flash Point | 235.2ºC |
Exact Mass | 708.51800 |
PSA | 153.75000 |
LogP | 7.79960 |
Index of Refraction | 1.512 |
Storage condition | −20°C |
Water Solubility | Soluble to 10 mM in Ethanol and to 10 mM in DMSO. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
![]() GHS07 |
---|---|
Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R22 |
Safety Phrases | 36-36/37/39-27-26 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | NO0650000 |
HS Code | 2941500000 |
Precursor 4 | |
---|---|
DownStream 0 |
HS Code | 2941500000 |
---|