Ionomycin

Modify Date: 2024-01-03 17:20:10

Ionomycin structure	Common Name	Ionomycin
	CAS Number	56092-81-0	Molecular Weight	709.00500
	Density	1.072 g/cm3	Boiling Point	817.2ºC at 760 mmHg
	Molecular Formula	C₄₁H₇₂O₉	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	235.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Ionomycin

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.

Name	ionomycin
Synonym	More Synonyms

Description	Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Research Areas >> Infection
Target	Calcium channel[1].
In Vitro	Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005[1]. It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
References	[1]. Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [2]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.

Density	1.072 g/cm3
Boiling Point	817.2ºC at 760 mmHg
Molecular Formula	C₄₁H₇₂O₉
Molecular Weight	709.00500
Flash Point	235.2ºC
Exact Mass	708.51800
PSA	153.75000
LogP	7.79960
Index of Refraction	1.512
Storage condition	−20°C
Water Solubility	Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NO0600000

CHEMICAL NAME :: Ionomycin

CAS REGISTRY NUMBER :: 56092-81-0

LAST UPDATED :: 199107

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C41-H70-O9

MOLECULAR WEIGHT :: 707.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,815,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36-36/37/39-27-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NO0650000
HS Code	2941500000

Precursor 4
CAS#:110497-18-2 ionomycin methy... CAS#:73814-77-4 (3R,4S)-1-(benz... CAS#:128329-77-1 (1S,2R,6R,4Z)-5... CAS#:128329-80-6 (1''R,1'R,2R,5S...
DownStream 0

HS Code	2941500000

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10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-

(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadienoic acid

Ionomycin

Ionomycin free acid,(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid

Ionomycin,Free Acid,from Streptomyces conglbatus

MFCD00036890

Ionomycinefreeacid

Ionomycin from Streptomyces conglobatus

IONOMYCIN,STREPTOMYCES CONGLOBATUS

Ionomycin free acid

Ionomycin,Free Acid,Streptomyces conglobatus

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ionomycin
Price: ￥888.0/1mg ￥3358.0/5mg ￥11698.0/25mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ionomycin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1450/14.1 mM*100 μL in Ethanol

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Ionomycin

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