145224-99-3

145224-99-3 structure

Name: CALP1 TFA
Chemical Name: calp1
CAS Number: 145224-99-3
Molecular Formula: C₄₀H₇₅N₉O₁₀
Molecular Weight: 842.07800
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-01-01 02:44:57
Modify Date: 2024-01-23 18:53:15
CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].

Name	calp1
Synonyms	VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS V-A-I-T-V-L-V-K Calcium-like peptide 1 H-VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS-OH CALP PEPTIDE MIMETIC OF CALCIUM CALCIUM-LIKE PEPTIDE

Description	CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR
Target	Kd: 88 µM (Calmodulin)[4]
References	[1]. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. [2]. R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. [3]. M K Manion, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306. [4]. M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85.