CALP1 TFA

Modify Date: 2025-10-08 17:13:50

CALP1 TFA structure	Common Name	CALP1 TFA
	CAS Number	145224-99-3	Molecular Weight	842.07800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₇₅N₉O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CALP1 TFA

CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].

Name	calp1
Synonym	More Synonyms

Description	CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR
Target	Kd: 88 µM (Calmodulin)[4]
References	[1]. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. [2]. R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. [3]. M K Manion, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306. [4]. M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85.

Molecular Formula	C₄₀H₇₅N₉O₁₀
Molecular Weight	842.07800
Exact Mass	841.56400
PSA	313.27000
LogP	3.51870

VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS

V-A-I-T-V-L-V-K

Calcium-like peptide 1

H-VAL-ALA-ILE-THR-VAL-LEU-VAL-LYS-OH

CALP

PEPTIDE MIMETIC OF CALCIUM

CALCIUM-LIKE PEPTIDE

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CALP1 TFA

Use of CALP1 TFA

Names

CALP1 TFA Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.