129623-01-4
129623-01-4 structure
- Name: GR 82334
- Chemical Name: 3-Bromocytisine
- CAS Number: 129623-01-4
- Molecular Formula: C69H91N15O16
- Molecular Weight: 1386.55000
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-08-02 18:11:45
- Modify Date: 2024-01-10 14:06:43
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GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
| Name | 3-Bromocytisine |
|---|
| Description | GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1]. |
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| Related Catalog | |
| In Vivo | GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1]. GR 82334 (10 nM-1 µM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2]. Animal Model: 3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2] Dosage: 10 nM, 100 nM, and 1 µM Administration: Lntrathecal injection between vertebrae L4 and L5 Result: Increased heat-induced foot withdrawal latency in mice. |
| References |
| Molecular Formula | C69H91N15O16 |
|---|---|
| Molecular Weight | 1386.55000 |
| Exact Mass | 1385.68000 |
| PSA | 479.25000 |
| LogP | 3.53680 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |