Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GR 46611
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: GR-46611
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

185259-85-2

185259-85-2 structure

185259-85-2 structure

Name: GR 46611
Chemical Name: (E)-3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide
CAS Number: 185259-85-2
Molecular Formula: C₂₃H₂₇N₃O₂
Molecular Weight: 377.47900
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2019-01-02 17:19:11
Modify Date: 2024-04-05 15:21:25
GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia[1][3].

Name	(E)-3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide
Synonyms	GR 4661 Mecamylamine hydrochloride

Description	GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia[1][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1D Receptor
In Vitro	GR-46611 (1 μM, 48 h) induces CEM cell proliferation[2]. Cell Proliferation Assay[2] Cell Line: CEM cells (human T lymphoblastic leukemia cell line) Concentration: 1 μM Incubation Time: 48 h Result: Induced a significant increase in cell proliferation by 37.0%.
In Vivo	GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1]. GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3]. GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4]. Animal Model: Dravet syndrome (DS) mice[1] Dosage: 0.01, 0.1 and 1 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Improved survival relative to vehicle treated controls with 89% surviving rate.
References	[1]. Paul G Hatini, et al. A 5-HT 1D -receptor agonist protects Dravet syndrome mice from seizure and early death. Eur J Neurosci. 2020 Nov;52(10):4370-4374. [2]. C Sibella-Argüelle, et al. The proliferation of human T lymphoblastic cells induced by 5-HT1B receptors activation is regulated by 5-HT-moduline. C R Acad Sci III. 2001 Apr;324(4):365-72. [3]. Baojun Gu, et al. Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. J Pharmacol Exp Ther. 2004 Sep;310(3):1266-72. [4]. M Skingle, et al. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. J Psychopharmacol. 1994 Jan;8(1):14-21.

Density	1.168g/cm3
Boiling Point	645.9ºC at 760mmHg
Molecular Formula	C₂₃H₂₇N₃O₂
Molecular Weight	377.47900
Flash Point	344.4ºC
Exact Mass	377.21000
PSA	57.36000
LogP	4.00110
Vapour Pressure	1.43E-16mmHg at 25°C
Index of Refraction	1.639
Storage condition	-20°C

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26