Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Spermine
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Purity: 98.0%
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71-44-3

71-44-3 structure

71-44-3 structure

Name: Spermine
Chemical Name: spermine
CAS Number: 71-44-3
Molecular Formula: C₁₀H₂₆N₄
Molecular Weight: 202.340
Catalog: Chemical pesticide Insecticide intermediate
Create Date: 2018-02-04 08:00:00
Modify Date: 2026-06-30 15:18:14
Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.

Name	spermine
Synonyms	N1,N1'-(Butane-1,4-diyl) SPERMINE FREE BASE extrapure bis(propane-1,3-diamine) N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE N,N'-Bis(3-aminopropyl)-1,4-diaminobutane N,N'-Bis(3-aminopropyl)tetramethylenediamine N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine) MFCD00012914 (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl}) amine 4,9-Diazadodecane-1,12-diamine Spermin n,n’-bis(3-aminopropyl)-4-butanediamine SOYASAPONIN IV(SH) 1,4-Diaminobutane, N,N'-bis(3-aminopropyl) 4,9-Diaza-1,12-dodecanediamine N,N'-Bis(3-aminopropyl)butane-1,4-diamine Spermine (Standd) Spermine N,N-Bis(3-aminopropyl)-1,4-diaminobutane BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE Gadobutrol Impurity 180 Monomer N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL N1,N4-bis(3-aminopropyl)-1,4-butanediamine MUSCULAMINE TETRAHYDROCHLORIDE 1,4-Butanediamine, N,N'-bis(3-aminopropyl) Spermine (NSC-268508 MUSCULAMINE HYDROCHLORIDE GERONTINE TETRAHYDROCHLORIDE N,N-Bis(3-aminopropyl)-1,4-diaminobutane~Gerontine~Musculamine~Neuridine DJtPAT N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE 1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE EINECS 200-754-2 SPERMINE >= N,N'-Bis(3-aminopropyl)-1,4-butanediamine Spermine with Best Price Fast Delivery Good Quality Gerontine\|\|\|Musculamine\|\|\|4,9-Diaza-1,12-dodecanediamine\|\|\|NSC 268508\|\|\|Neuridine 1,4-Butanediamine, N1,N4-bis(3-aminopropyl) N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE NEURIDINE TETRAHYDROCHLORIDE SPERMINE TETRAHYDROCHLORIDE Spermine,N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine n,n’-bis(3-aminopropyl)-4-diaminobutane 1,4-Bis(aminopropyl)butanediamine N,N'-Bis(3-aminopropyl)butan-1,4-diamin N,N'-bis(3-aminopropyl)butane-1,4-diamine Spermine in methanol 4,9-diazadodecamethylenediamine SPERMINE HYDROCHLORIDE SPERMINE FREE BASE CELL CULTURE TESTED 1,5,10,14-Tetraazatetradecane N,NBis(2-aminopropyl)-1,4-butane-diamine, N,NBis(2-aminopropyl)tetramethylenediamine Sperminedihydrate NEURIDINE HYDROCHLORIDE

Description	Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1].
References	[1]. Ha HC, et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5.

Density	0.9±0.1 g/cm3
Boiling Point	308.4±0.0 °C at 760 mmHg
Melting Point	310-311 °C (dec.)(lit.)
Molecular Formula	C₁₀H₂₆N₄
Molecular Weight	202.340
Flash Point	175.6±22.6 °C
Exact Mass	202.215744
PSA	76.10000
LogP	-0.96
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.485
Storage condition	2-8°C
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7175000

CHEMICAL NAME :: 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-

CAS REGISTRY NUMBER :: 71-44-3

BEILSTEIN REFERENCE NO. :: 1750791

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H26-N4

MOLECULAR WEIGHT :: 202.40

WISWESSER LINE NOTATION :: Z3M4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 2 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C: Corrosive;Xi: Irritant;
Risk Phrases	R34
Safety Phrases	S26-S36-S45-S36/37/39
RIDADR	UN 3259 8/PG 2
WGK Germany	3
RTECS	EJ7230000
Packaging Group	III
Hazard Class	8
HS Code	2929909090

Precursor 7
14209-32-6 78707-11-6 78706-92-0 12651-38-6
124-20-9 110-60-1 73397-39-4
DownStream 10
306-67-2 123-75-1 120-94-5 7664-41-7
25593-72-0 124-20-9 109-76-2 123-38-6
136587-13-8 352-92-1

HS Code	2921290000
Summary	2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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