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71-44-3

71-44-3 structure
71-44-3 structure
  • Name: Spermine
  • Chemical Name: spermine
  • CAS Number: 71-44-3
  • Molecular Formula: C10H26N4
  • Molecular Weight: 202.340
  • Catalog: Chemical pesticide Insecticide intermediate
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 11:56:22
  • Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.
Name spermine
Synonyms Spermin
1,4-Butanediamine, N,N-bis(3-aminopropyl)-
MUSCULAMINE HYDROCHLORIDE
EINECS 200-754-2
N,N'-Bis(3-aminopropyl)butane-1,4-diamine
N,N'-Bis(3-aminopropyl)-1,4-butanediamine
N,N'-Bis(3-aminopropyl)butan-1,4-diamin
N,N'-Bis(3-aminopropyl)-1,4-diaminobutane
N,N'-Bis(3-aminopropyl)tetramethylenediamine
Spermine
SPERMINE HYDROCHLORIDE
MFCD00012914
1,5,10,14-Tetraazatetradecane
NEURIDINE HYDROCHLORIDE
N1,N4-bis(3-aminopropyl)-1,4-butanediamine
Description Spermine functions directly as a free radical scabenger to protect DNA from free radical attack.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1].
References

[1]. Ha HC, et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5.
Density 0.9±0.1 g/cm3
Boiling Point 308.4±0.0 °C at 760 mmHg
Melting Point 310-311 °C (dec.)(lit.)
Molecular Formula C10H26N4
Molecular Weight 202.340
Flash Point 175.6±22.6 °C
Exact Mass 202.215744
PSA 76.10000
LogP -0.96
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.485
Storage condition 2-8°C
Water Solubility H2O: 1 M at 20 °C, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ7175000
CHEMICAL NAME :
1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
CAS REGISTRY NUMBER :
71-44-3
BEILSTEIN REFERENCE NO. :
1750791
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H26-N4
MOLECULAR WEIGHT :
202.40
WISWESSER LINE NOTATION :
Z3M4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
2 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C: Corrosive;Xi: Irritant;
Risk Phrases R34
Safety Phrases S26-S36-S45-S36/37/39
RIDADR UN 3259 8/PG 2
WGK Germany 3
RTECS EJ7230000
Packaging Group III
Hazard Class 8
HS Code 2929909090
HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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