567-03-3

567-03-3 structure

Name: 3alpha,21-dihydroxy-5beta-pregnan-20-one
Chemical Name: Tetrahydro 11-Deoxycorticosterone
CAS Number: 567-03-3
Molecular Formula: C₂₁H₃₄O₃
Molecular Weight: 334.49300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-06-01 08:00:00
Modify Date: 2026-07-01 18:34:10
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].

Name	Tetrahydro 11-Deoxycorticosterone
Synonyms	3-ALPHA,5-BETA-TETRAHYDRODEOXYCORTICOSTERONE TETRAHYDRO CMPD ''Q'' TETRAHYDROCORTEXONE TETRAHYDRODEOXYCORTICOSTERONE 5β-PREGNAN-3α, 21-DIOL-20-ONE TETRAHYDRODESOXYCORTICOSTERONE TH DOC 21-HYDROXYPREGNANOLONE 5B-pregnane-3A-21-diol-20-one 2-hydroxy-1-(3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethanone 21-Hydroxypregnanolone (Solution) (3α,5β)-3,21-Dihydroxypregnan-20-one 2-hydroxy-1-[(5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 11-Deoxytetrahydrocorticosterone α,21-Dihydroxy-5β-pregnan-20-one 5-BETA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE tetrahydrodeoxycorticosterone Deoxytetrahydrocorticosterone TETRAHYDRO DOC 5β-Pregnan-3α,21-diol-20-one TETRAHYDRO SUBSTANCE 'Q'

Description	Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1]. In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].
In Vivo	Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species[2].
References	[1]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [2]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.