567-03-3

567-03-3结构式

中文名	21-羟基孕烷醇酮
英文名	Tetrahydro 11-Deoxycorticosterone
中文别名	5Β-孕聚糖-3Α,21-二醇-20-酮 21-羟基孕烷酮 21-羟基孕烷酮(溶液) 21-羟孕烷醇酮四氢11-脱氧皮质酮
英文别名	3-ALPHA,5-BETA-TETRAHYDRODEOXYCORTICOSTERONE TETRAHYDRO CMPD ''Q'' TETRAHYDROCORTEXONE TETRAHYDRODEOXYCORTICOSTERONE 5β-PREGNAN-3α, 21-DIOL-20-ONE TETRAHYDRODESOXYCORTICOSTERONE TH DOC 21-HYDROXYPREGNANOLONE 5B-pregnane-3A-21-diol-20-one 2-hydroxy-1-(3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethanone 21-Hydroxypregnanolone (Solution) (3α,5β)-3,21-Dihydroxypregnan-20-one 2-hydroxy-1-[(5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 11-Deoxytetrahydrocorticosterone α,21-Dihydroxy-5β-pregnan-20-one 5-BETA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE tetrahydrodeoxycorticosterone Deoxytetrahydrocorticosterone TETRAHYDRO DOC 5β-Pregnan-3α,21-diol-20-one TETRAHYDRO SUBSTANCE 'Q'

描述	四氢脱氧皮质酮是一种神经甾体,是GABAA受体的一种有效的正变构调节剂(PAM)。四氢脱氧皮质酮具有强大的神经抑制特性[1][2]。
相关类别	信号通路 >> 跨膜转运 >> GABA受体研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> GABA受体
体外研究	生理浓度下的内源性神经甾体四氢脱氧皮质酮(THDOC)选择性地增强由αβδ受体介导的强直电流[1]。在海马,10nm四氢脱氧皮质酮通过增强强直性αβδ受体电流降低神经元兴奋性。在丘脑皮层神经元中,尽管100nm四氢脱氧皮质酮能增强强直电流,但10nm四氢脱氧皮质酮不能[1]。
体内研究	中毒性肝损伤所致肝性脑病(HE)小鼠脑组织中四氢脱氧皮质酮(THDOC)的浓度足以诱导同种动物镇静[2]。
参考文献	[1]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [2]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.