63631-36-7

63631-36-7 structure

Name: Asperphenamate
Chemical Name: asperphenamate
CAS Number: 63631-36-7
Molecular Formula: C₃₂H₃₀N₂O₄
Molecular Weight: 506.59200
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-06-11 07:50:16
Modify Date: 2024-04-02 12:28:13
Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].

Name	asperphenamate
Synonyms	Auranamide N-benzoylphenylalaninyl-N-benzoylphenylalaninate N-Benzoyl-L-phenylalanine (S)-2-benzoylamino-3-phenylpropyl ester (2S)-2-(Benzoylamino)-3-phenylpropanoic acid (2S)-2-(benzoylamino)-3-phenylpropyl ester

Description	Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
In Vitro	Asperphenamate can inhibit cancer cell proliferation by fully inducing autophagy. asperphenamate showed inhibition effects against cathepsin L. At the same time, it also displayed weak inhibitory ability against cathepsin S.
References	[1]. Alice M.Clark, et al. Synthesis of asperphenamate, a novel fungal metabolite. Phytochemistry [2]. LeiYuan, et al. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine. Chinese Chemical Letters Volume 21, Issue 2, February 2010, Pages 155-158. [3]. Yuan L, et al. Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells. Bioorg Chem. 2018 Dec;81:672-680.