Asperphenamate

Modify Date: 2024-04-02 12:28:13

Asperphenamate Structure
Asperphenamate structure
Common Name Asperphenamate
CAS Number 63631-36-7 Molecular Weight 506.59200
Density 1.198g/cm3 Boiling Point 774.3ºC at 760 mmHg
Molecular Formula C32H30N2O4 Melting Point N/A
MSDS N/A Flash Point 422.1ºC

 Use of Asperphenamate


Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].

 Names

Name asperphenamate
Synonym More Synonyms

 Asperphenamate Biological Activity

Description Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].
Related Catalog
In Vitro Asperphenamate can inhibit cancer cell proliferation by fully inducing autophagy. asperphenamate showed inhibition effects against cathepsin L. At the same time, it also displayed weak inhibitory ability against cathepsin S.
References

[1]. Alice M.Clark, et al. Synthesis of asperphenamate, a novel fungal metabolite. Phytochemistry

[2]. LeiYuan, et al. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine. Chinese Chemical Letters Volume 21, Issue 2, February 2010, Pages 155-158.

[3]. Yuan L, et al. Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells. Bioorg Chem. 2018 Dec;81:672-680.

 Chemical & Physical Properties

Density 1.198g/cm3
Boiling Point 774.3ºC at 760 mmHg
Molecular Formula C32H30N2O4
Molecular Weight 506.59200
Flash Point 422.1ºC
Exact Mass 506.22100
PSA 84.50000
LogP 5.39400
Index of Refraction 1.611

 Synonyms

Auranamide
N-benzoylphenylalaninyl-N-benzoylphenylalaninate
N-Benzoyl-L-phenylalanine (S)-2-benzoylamino-3-phenylpropyl ester
(2S)-2-(Benzoylamino)-3-phenylpropanoic acid (2S)-2-(benzoylamino)-3-phenylpropyl ester
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