495-85-2

• 常用中文名：麻醉椒苦素
• 常用英文名：Methylsticin
• CAS号：495-85-2
• 分子式：C₁₅H₁₄O₅
• 分子量：274.269
• 相关类别： 分析化学 标准品 分析标准品
• 发布时间：2018-07-05 10:49:32
• 更新时间：2025-08-21 18:26:40
• Methylsticin 是从卡瓦根中分离出来的一种卡瓦内酯。Methylsticin 具有抑制破骨细胞形成的活性。

名称

• 中文名: 麻醉椒苦素
• 英文名: (2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
• 中文别名: (R)-5,6-二氢-4-甲氧基-6-(3,4-(亚甲二氧基)苯乙烯基)-2H-吡喃-2-酮; 醉人素
• 英文别名: 2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6S)-; (E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydropyran-2-one; 2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-; (+-)-Methysticin; (R-(E))-6-(2-(1,3-Benzodioxol-5-yl)ethenyl)-5,6-dihydro-4-methoxy-2H-pyran-2-one; [R-(E)]-6-[2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one; 6-(3',4'-Methylenedioxystyryl)-4-methoxy-5,6-dihydro-2H-pyran-2-one; Kavahin; (6S)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; Methysticin; 4-Methoxy-6-[b-(3',4'-methylenedioxyphenyl)vinyl]-5,6-dihydro-a-pyrone; (6R)-6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; 5-Hydroxy-3-methoxy-7-[3,4-(methylenedioxy)phenyl]-2,6-heptadienoic Acid d-Lactone; 6-(2-benzo[1,3]dioxol-5-yl-vinyl)-4-methoxy-5,6-dihydro-pyran-2-one; (E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; (R)-5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one; (6R)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; Kavatin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 496.5±45.0 °C at 760 mmHg
• 熔点: 139-140.5ºC
• 分子式: C₁₅H₁₄O₅
• 分子量: 274.269
• 闪点: 223.9±28.8 °C
• 精确质量: 274.084137
• PSA: 53.99000
• LogP: 1.81
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.597
• 储存条件: 2-8°C

生物活性

• 描述: Methylsticin 是从卡瓦根中分离出来的一种卡瓦内酯。Methylsticin 具有抑制破骨细胞形成的活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Shoujun Chen, et al. Methods of inhibiting osteoclast activity. US20030229137A1.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ0517000 CHEMICAL NAME : 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)- , (R)- CAS REGISTRY NUMBER : 495-85-2 BEILSTEIN REFERENCE NO. : 0091701 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C15-H14-O5 MOLECULAR WEIGHT : 274.29 WISWESSER LINE NOTATION : T56 BO DO CHJ G1U1- FT6OV CUTJ DO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

1092383-57-7 1682-37-7 ~58% 495-85-2

文献：Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616

1092383-57-7 5876-51-7 ~42% 495-85-2

文献：Amaral, Patricia A.; Gouault, Nicolas; Roch, Myriam Le; Eifler-Lima, Vera L.; David, Michele Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6607 - 6609

117081-50-2 ~% 495-85-2

文献：Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616

120-57-0 ~% 495-85-2

文献：Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145

58095-77-5 ~% 495-85-2

文献：Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145

26536-93-6 58095-77-5 ~% 495-85-2

文献：Klohs et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 1829

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