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69056-38-8

69056-38-8 structure
69056-38-8 structure
  • Name: (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
  • Chemical Name: sapropterin dihydrochloride
  • CAS Number: 69056-38-8
  • Molecular Formula: C9H17Cl2N5O3
  • Molecular Weight: 314.17
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-09-13 21:50:27
  • Modify Date: 2026-07-01 17:45:43
  • Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.
Name sapropterin dihydrochloride
Synonyms 6R-BH4
(6R,1'R,2'S)-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin
1-(2-Amino-4-hydroxy-5,6,7,8-tetrahydropteridin-7-yl)propane-1,2-diol dihydrochloride
Sapropterin DiHCl
(6R)-5,6,7,8-tetrahydro-L-biopterin
4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)- (9CI)
Dapropterin dihydrochloride
BH4 DIHYDROCHLORIDE
(6R)-5,6,7,8-TETRAHYDRO-BIOPTERIN DIHYDROCHLORIDE
Kuvan
sapropterinum
(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one
Tetrahydrobiopterin, Dihydrochloride
THB, 2HCL
[6R-[6R*(1R*,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE
Shiratori SN 0588
Sapropterin HCl
(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride
5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinondihydro
[6R-[6R*(1R*,2S*)]]-2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone
Tetrahydro-L-Biopterin (dihydrochloride)s
Tetrahydrobiopterin (THB) dihydrochloride, >=
(6R)-Tetrahydrobiopterin hydrochloride
Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride
(R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one hydrochloride
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
6b-5,6,7,8-Tetrahydro-L-biopterin
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one,dihydrochloride
sun0588
6R-Tetrahydro-L-biopterin
Sapropterin DiHCl (Dehydro Siapterin DiHCl)
(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin
sapropterina
TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE
Sapropterin Dihydrochloride
(R)-2-Amino-6-((1R,2S)-1,2-dihydroxy-propyl)-5,6,7,8-tetrahydropteridin-4(1H)-one HCl
(6r-(6r*(1r*,2s*)))-chlorid
Tetrahydro-L-Biopterin (hydrochloride)
4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]
(6r)-tetrahydrobiopterinhydrochloride
(6R)-L-erythro-Tetrahydrobiopterin
Sapropterin dihydrochloride
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
Sapropterin (dihydrochloride)
Tetrahydro-L-biopterin2HCl
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
(6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl
Tetrahydro -L- biopterin
Dapropterin
(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone
(6R)-Tetrahydrobiopterin
6R-tetahydrobiopterin
(6R)-5,6,7,8-Tetrahydro-biopterin,2HCl,6R-BH4
Biopten
(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, (6R)-, hydrochloride (1:2)
Sapropterin (Tetrahydrobiopterin) Dihydrochloride
BioMin
R-THBP
MFCD00891665
(6R)-5,6,7,8-Tetrahydrobiopterin
(6R)-tetrahydrobiopterin dihydrochloride
Tetrahydrobiopterin/BH4
(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride
Sapropterin
[6R-[6R*(1R*,2S*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone . 2HCl
kuvan
Tetrahydrobiopterin (THB) dihydrochloride
(6R-(6R*(1R*,2S*)))-5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone dihydrochloride
R-THBP6R-BH4
6R-BH4 dihydrochloride
sapropterinhydrochloride
(6b)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
(6R)-5,6,7,8-Tetrahydro-biopterin, Dihydrochloride, 6R-BH4
2-AMINO-6R-(1R,2S-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE, DIHYDROCHLORIDE
6-BETA-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
4(3H)-Pteridinone,2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, hydrochloride(1:2), (6R)
(6R)-BH4 2HCL
4(1H)-pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, (6R)-, dihydrochloride
(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochlori
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
(6R)-Tetrahydro-L-biopterindihydrochloride
Sapropterin(Tetrahydrobiopterin)
Description Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.
Related Catalog
References

[1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11.

[2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27

[3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331.

[4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16
Density 1.9±0.1 g/cm3
Boiling Point 506.6±60.0 °C at 760 mmHg
Molecular Formula C9H17Cl2N5O3
Molecular Weight 314.17
Flash Point 260.2±32.9 °C
PSA 136.29000
LogP -4.22
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.822
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO3516500
CHEMICAL NAME :
4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-
CAS REGISTRY NUMBER :
69056-38-8
LAST UPDATED :
199603
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C9-H15-N5-O3.2Cl-H
MOLECULAR WEIGHT :
314.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1084 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
239 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 43,1191,1992
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases R22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UO3516500
HS Code 2933990090
Precursor  1

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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