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22150-76-1

22150-76-1 structure

22150-76-1 structure

Name: 6-Biopterin
Chemical Name: biopterin
CAS Number: 22150-76-1
Molecular Formula: C₉H₁₁N₅O₃
Molecular Weight: 237.215
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-07-26 16:52:35
Modify Date: 2026-07-15 12:03:38
6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.

Name	biopterin
Synonyms	Biopterin, coenzyme and cofactor of iNOS activity NSC-339699 L-BIOPTERIN D-erythro-Biopterin 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(3H)-one 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one 6-Biopterin, 10 mM in DMSO Sapropterin Dihydrochloride Impurity C Pterin HB2 BIOPTERIN EINECS 244-807-8 L-erythro-Biopterin L-Biopterin(6-Biopterin) (1'R,2'S)-BIOPTERIN (1'S,2'R)-Biopterin 2-AMINO-4-HYDROXY-6-[1,2-DIHYDROXYPROPYL]PTERIDINE L-ERYTHRO-6-(1,2-DIHYDROXYPROPYL)PTERIN L-Biopterin [L-erythro-Biopterin] 2-amino-6-(1,2-dihydroxypropyl)-,(s-(r,s))-4(1h)-pteridinon 2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one Sapropterin Impurity 15 (Biopterin) 2-Amino-6-[(1S,2R)-1,2-dihydroxypropyl]pteridine-4(3H)-one 2-amino-6-(l-erythro-1,2-dihydroxypropyl)-4(3h)-pteridinon 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone MFCD00036787 [S-(R,S)]-2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one L-Biopterin 2-Amino-6-(1,2-dihydroxypropyl)- 4(1H)-pteridinone pterinhb2 (-)-Biopterin L-Erythro-Biopterin 2-Amino-6-[(1S,2R)-1,2-dihydroxypropyl]pteridin-4(1H)-one 6-BIOPTERIN L-Biopterin(NSC 339699,L-erythro-Biopterin) L- BiopterinQ: What is L- Biopterin Q: What is the CAS Number of L- Biopterin Q: What is the storage condition of L- Biopterin Q: What e the applications of L- Biopterin (1R,2S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin (1R,2S)-1-(4-Hydroxy-2-imino-1,2-dihydro-6-pteridinyl)-1,2-propanediol [S-(R,S)]-2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone 6-Biopterin,(1’R,2’S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin 2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)pteridin-4(1H)-one L-Biopterin,2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl] Pterin H B2

Description	6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	6-biopterin is extremely cytotoxic to human melanocytes under in vitro conditions. Thioredoxin reductase has the capacity to reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridine reductase or reduced glutathione. (6R)5,6,7,8 tetrahydrobiopterin undergoes redox-cycling by its oxidation to quinonoid dihydrobiopterin and to 6-biopterin through consecutive two electron oxidation reactions[1].
References	[1]. Schallreuter KU, et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.

Density	1.9±0.1 g/cm3
Boiling Point	563.4±60.0 °C at 760 mmHg
Melting Point	>210°C dec.
Molecular Formula	C₉H₁₁N₅O₃
Molecular Weight	237.215
Flash Point	294.5±32.9 °C
Exact Mass	237.086182
PSA	138.01000
LogP	-3.84
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.822

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO3506000

CHEMICAL NAME :: 4(3H)-Pteridinone, 2-amino-6-(L-erythro-1,2-dihydroxypropyl)-

CAS REGISTRY NUMBER :: 22150-76-1

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N5-O3

MOLECULAR WEIGHT :: 237.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 879 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 10 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,147,1984

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UO3506000
HS Code	2933990090

Precursor 6
62933-57-7 35011-47-3 81827-31-8 1104608-07-2
13039-56-0 4066-47-1
DownStream 7
712-30-1 948-60-7 69056-38-8 13039-82-2
65434-55-1 62989-33-7 62961-57-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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