6151-40-2
6151-40-2 structure
- Name: Quinidine hydrochloride monohydrate
- Chemical Name: quinidine hydrochloride
- CAS Number: 6151-40-2
- Molecular Formula: C20H27ClN2O3
- Molecular Weight: 378.89300
- Catalog: Pharmaceutical intermediate Heterocyclic compound Quinoline compound
- Create Date: 2018-08-03 09:25:20
- Modify Date: 2024-01-08 10:51:41
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Quinidine hydrochloride monohydrate is a clinical anti-arrythmic drug which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.
| Name | quinidine hydrochloride |
|---|---|
| Synonyms |
Quinidine monohydrate hydrochloride
QUINIDINE HYDROCHLORIDE MONOHYDRATE |
| Description | Quinidine hydrochloride monohydrate is a clinical anti-arrythmic drug which is also a potent blocker of K+ channel with an IC50 of 19.9 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 19.9 μM (K+ channel)[1] |
| In Vitro | Quinidine hydrochloride monohydrate blocks WT mSlo3 (KCa5.1) channels with an IC50 of 19.9±1.41 μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC50 of 2.42±0.60 μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC50 of 38.4±6.77 μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence[1]. |
| In Vivo | Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side[2]. |
| Cell Assay | Mouse (m) Slo3 (KCa5.1) channels or mutant forms are expressed in Xenopus oocytes and currents recorded with 2-electrode voltage-clamp. Gain-of-function mSlo3 mutations are used to explore the state-dependence of the inhibition. The interaction between Quinidine hydrochloride monohydrate and mSlo3 channels is modelled by in silico docking[1]. |
| Animal Admin | 24 rats are randomly divided into three groups with eight rats in each group. Groups Q1, Q3, and Q5 receive Quinidine hydrochloride monohydrate 1, 3, and 5 μmol, respectively, in 5 % glucose 0.1 mL. The sciatic nerve is exposed by making an incision from the left sciatic notch to the distal thigh. The subcutaneous tissue is bluntly dissected to expose the biceps femoris. The sciatic nerve is freed from its investing fascia. The procedure is then repeated on the right side. The somato-sensory evoked potential (SSEP) and compound muscle action potentials (CMAP) are recorded at baseline, immediately after Quinidine hydrochloride monohydrate treatment, then every 15 min thereafter for 1 h, then every 30 min thereafter for 3 h. The animals are allowed to recover and then kept separately for 2 weeks. After performing behavioral examinations, electrophysiological examinations are performed with the animals under intra-peritoneal anesthesia[2]. |
| References |
| Boiling Point | 495.9ºC at 760 mmHg |
|---|---|
| Melting Point | 258-259ºC |
| Molecular Formula | C20H27ClN2O3 |
| Molecular Weight | 378.89300 |
| Flash Point | 253.7ºC |
| Exact Mass | 378.17100 |
| PSA | 54.82000 |
| LogP | 3.84880 |
| Storage condition | 2-8℃ |
|
Section 1. Chemical Product and Company Identification Quinidine HCl monohydrateCatalog QU104 Common Name/ Number(s). Trade Name CAS#6151-40-2
Manufacturer RTECSVA5750000 SPECTRUM CHEMICAL MFG. CORP. TSCATSCA 8(b) inventory: Quinidine HCl monohydrate Commercial Name(s)Not available. CI# Not available. Synonym6'-Methoxycinchonan-9-ol hydrochloride IN CASE OF EMERGENCY Not available. Chemical Name Chemical FamilyNot available.CALL (310) 516-8000 C20H24N2O2.HCl.H2O Chemical Formula SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Quinidine HCl monohydrate6151-40-2100 Toxicological DataQuinidine HCl monohydrate on IngredientsLD50: Not available. LC50: Not available. Section 3. Hazards Identification Potential Acute Health Effects Very hazardous in case of ingestion. Hazardous in case of eye contact (irritant), of inhalation. Potential Chronic HealthVery hazardous in case of ingestion. EffectsHazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Quinidine HCl monohydrate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention. Skin ContactNo known effect on skin contact, rinse with water for a few minutes. Serious Skin ContactNot available. InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious InhalationNot available. IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Quinidine HCl monohydrate Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible. StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a a Large Spillspecialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystals solid.)OdorOdorless. TasteBitter. Molecular Weight378.9 g/mole ColorWhite. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointDecomposes. (259°C or 498.2°F) Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water, methanol. SolubilitySoluble in methanol. Partially soluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityNot available. Incompatibility with various Not available. substances Quinidine HCl monohydrate CorrosivityNon-corrosive in presence of glass. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryEye contact. Inhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion. HumansHazardous in case of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onHuman: passes through the placenta, excreted in maternal milk. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport Quinidine HCl monohydrate DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Quinidine HCl monohydrate Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available.. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R36- Irritating to eyes. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection j WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Not applicable. Lab coat. Not applicable. Splash goggles. SECTION 16 - ADDITIONAL INFORMATION N/A |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn,Xi |
| Risk Phrases | 20/21/22-36/37/38 |
| Safety Phrases | 36-26 |
| RIDADR | UN 2811 6.1/PG 3 |